PIRRO N.
- Country
- France
- Department
- Surgery
Research Overview
- Phase II Multicenter Randomized Trial of PIPAC and Systemic Chemotherapy Versus Systemic Chemotherapy Alone in First-Line Treatment of Malignant Peritoneal Mesothelioma
- Evaluation of Systemic Chemotherapy and Targeted Therapy with or without PIPAC in Advanced Colorectal Peritoneal Metastases: A Phase II Randomized Trial
Data & Insights
Has run more than one trial at 8 of 16 partner sites.
Specializations
Thoracic and head and neck oncology
Clinical activity is centered on non-small cell lung cancer, small cell lung cancer, and advanced head and neck squamous cell carcinoma, with additional interest in resectable and unresectable tumors of the upper aerodigestive tract and other solid malignancies.
- Advanced NSCLC and molecularly defined lung cancer
- SCLC and other thoracic tumors
- Head and neck squamous cell carcinoma
- Resectable and recurrent solid tumors
The oncology profile also includes biomarker-driven treatment in HER2-, EGFR-, ALK-, RET-, and KRAS-altered cancers, reflecting a strong focus on precision cancer care.
Digestive and hepatobiliary malignancies
Research interests extend to colorectal cancer, gastric cancer, esophageal cancer, pancreatic cancer, biliary tract cancer, and hepatocellular carcinoma, including advanced, metastatic, and locally advanced disease settings.
- Colorectal cancer and peritoneal metastases
- Gastric and esophageal malignancies
- Pancreatic and biliary tract cancer
- Hepatocellular carcinoma
Additional involvement includes gastrointestinal stromal tumors and rare abdominal tumor types, supporting therapeutic development across complex gastrointestinal oncology.
Melanoma, sarcoma, and rare solid tumors
The investigator is engaged in studies of melanoma, soft tissue sarcoma, osteosarcoma, Ewing sarcoma, chondrosarcoma, and other uncommon solid tumors, including advanced and refractory presentations.
- Melanoma, including metastatic and resected disease
- Soft tissue sarcoma and bone sarcoma
- Chondrosarcoma and other rare tumors
- Neuroendocrine tumors and mesothelioma
Therapeutic interest also covers rare cancer populations with limited standard options, where novel immunotherapy and targeted approaches are being explored.
Autoimmune, inflammatory, and neuromuscular disease
Clinical research includes Crohn’s disease, ulcerative colitis, sarcoidosis, vasculitis, lupus nephritis, myasthenia gravis, and pemphigus, alongside other immune-mediated disorders.
- Inflammatory bowel disease
- Systemic vasculitis and giant cell arteritis
- Myasthenia gravis and pemphigus diseases
- Connective tissue disease and interstitial lung disease
There is also involvement in neuromuscular and autoimmune kidney disease areas, including IgA nephropathy and membranous nephropathy.
Cardiovascular, respiratory, and neurologic medicine
Additional activity spans myocardial infarction, heart failure, arrhythmia, stroke, pulmonary fibrosis, asthma, and migraine, with interest in acute and chronic disease management.
- Acute coronary syndromes and cardiac arrest
- Stroke and thromboembolic disease
- Interstitial lung disease and pulmonary hypertension
- Neurologic disorders including ALS and multiple sclerosis
The portfolio also includes kidney disease and metabolic disorders, broadening the therapeutic scope beyond oncology and immune-mediated disease.
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