Pietro Manuel F.
- Country
- Italy
- Department
- UOC di Nefrologia
Research Overview
- Evaluation of Ravulizumab Efficacy and Safety in Adult Patients with Immunoglobulin A Nephropathy: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
- Efficacy and Safety of Efepoetin Alfa Versus Darbepoetin Alfa in Anemia Management for Chronic Kidney Disease Patients on Dialysis
- Evaluation of Sparsentan Versus Irbesartan on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis (FSGS)
Data & Insights
Has run more than one trial at 96 of 455 partner sites.
Specializations
Nephrology and Dialysis
Clinical research activity in chronic kidney disease, end-stage kidney disease, and dialysis-related complications, with attention to kidney-focused inflammatory and cardiovascular risk.
- Immunoglobulin A nephropathy
- Focal segmental glomerulosclerosis
- Chronic kidney disease in type 2 diabetes mellitus
- Anemia in patients with chronic kidney disease on dialysis
- Atherosclerotic cardiovascular disease in ESKD
Therapeutic interest also extends to inflammation-linked renal and vascular outcomes, including kidney protection, proteinuria reduction, and cardiovascular risk modification in advanced renal disease.
Cardiovascular and Thrombotic Disease
Research involvement includes prevention and treatment of atherosclerotic cardiovascular disease, myocardial infarction, stroke, and post-procedural thrombotic risk, with emphasis on event reduction.
- Acute ischemic stroke
- Transient ischemic attack
- Venous thromboembolism
- TAVI-related adverse cardiovascular events
- Heart failure with preserved or mildly reduced ejection fraction
Therapeutic focus also includes lipid lowering, antithrombotic strategies, and anti-inflammatory approaches in high-risk cardiovascular populations.
Hematologic Malignancies and Transplantation
Clinical trial work spans leukemias, lymphomas, and transplant-associated complications, with strong involvement in blood cancer treatment and post-transplant care.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Peripheral T-cell lymphoma
- Hematopoietic stem cell transplant-associated thrombotic microangiopathy
Interest also includes treatment-resistant disease, molecularly defined subtypes, and complications arising after hematopoietic stem cell transplantation.
Solid Tumors and Genitourinary Oncology
Research activity covers advanced malignancies across the lung, bladder, prostate, pancreas, and biliary tract, with a notable focus on uro-oncology and thoracic oncology.
- Non-small cell lung cancer
- Muscle invasive bladder cancer
- Metastatic prostate cancer
- Pancreatic ductal adenocarcinoma
- Biliary tract cancer
Therapeutic domains also include targeted and immune-based approaches for biomarker-defined disease, especially in lung, bladder, and prostate cancer.
Immune-Mediated, Respiratory, and Metabolic Disorders
Additional research interests include chronic inflammatory disease, airway disease, inherited metabolic conditions, and endocrine disorders, reflecting a broad internal medicine portfolio.
- Psoriatic arthritis
- Severe eosinophilic asthma
- Cystic fibrosis
- Type 1 diabetes
- Obesity and type 2 diabetes
Therapeutic interest further extends to neurologic and autoimmune conditions, including multiple sclerosis, epilepsy, and systemic inflammatory disease.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.