Pietro L.
- Country
- Italy
- Department
- Gastroenterology and Hepatology
Research Overview
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Study of Efimosfermin Alfa in Adults with Biopsy‑Confirmed F2–F3 Metabolic Dysfunction‑Associated Steatohepatitis
- Phase 2 Study of Durvalumab plus Tremelimumab with Lenvatinib Versus Durvalumab plus Tremelimumab in Unresectable Intermediate/Advanced Hepatocellular Carcinoma
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Study of Efimosfermin Alfa Safety and Tolerability in Adults with F2‑F3 Metabolic Dysfunction‑Associated Steatohepatitis
Data & Insights
Has run more than one trial at 228 of 405 partner sites.
Specializations
Hepatology and chronic liver disease
Clinical activity centers on chronic hepatitis B, hepatitis D, metabolic dysfunction-associated steatohepatitis, non-alcoholic steatohepatitis, primary biliary cholangitis, primary sclerosing cholangitis, cirrhosis, portal hypertension, hepatic encephalopathy, and hepatocellular carcinoma.
- Viral hepatitis
- Steatotic liver disease
- Cholestatic liver disorders
- Advanced liver disease
The investigator also engages in studies addressing alcohol-related liver disease and liver-related complications linked to progressive fibrosis and decompensation.
Inflammatory bowel disease and digestive disorders
Research interests include Crohn’s disease, ulcerative colitis, bowel urgency, fistulizing perianal disease, intestinal malabsorption, and broader digestive system diseases.
- Crohn’s disease
- Ulcerative colitis
- Intestinal malabsorption
- Functional bowel symptoms
Trial involvement extends to therapeutic approaches for persistent inflammatory activity and symptom control in complex gastrointestinal disease.
Hematology, blood disorders, and transplant-related complications
The investigator is involved in studies of myelofibrosis, myelodysplastic syndromes, acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, lymphomas, autoimmune cytopenias, hemophilia, von Willebrand disease, and paroxysmal nocturnal hemoglobinuria.
- Myeloid malignancies
- Lymphoid malignancies
- Bleeding disorders
- Complement-mediated hematologic disease
Additional activity includes graft-versus-host disease and other complications associated with hematopoietic stem cell transplantation.
Autoimmune, dermatologic, and rheumatologic disease
Clinical research includes systemic lupus erythematosus, lupus nephritis, rheumatoid-spectrum inflammatory disease, juvenile idiopathic arthritis, atopic dermatitis, bullous pemphigoid, hidradenitis suppurativa, psoriasis, vitiligo, and pruritic inflammatory skin disease.
- Systemic autoimmunity
- Inflammatory skin disease
- Arthritic disorders
- Immune-mediated nephritis
His trial portfolio also covers thyroid eye disease and other immune-driven conditions with substantial inflammatory burden.
Cardiometabolic, renal, and neurodegenerative disease
Ongoing work spans type 2 diabetes, obesity, cardiovascular disease, atrial fibrillation, heart failure, chronic kidney disease, IgA nephropathy, complement 3 glomerulopathy, amyloid cardiomyopathy, Alzheimer’s disease, and frontotemporal dementia.
- Metabolic disease
- Kidney disease
- Cardiovascular risk
- Neurocognitive disorders
Research interests also include retinal disease, macular degeneration, and other chronic conditions with multi-organ therapeutic relevance.
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