Perrine D. B.
- Country
- France
- Department
- Rhumatologie pédiatrique
Research Overview
Data & Insights
Has run more than one trial at 0 of 10 partner sites.
Specializations
Pediatric Autoimmune and Inflammatory Arthritis
The investigator concentrates on childhood arthritides that combine autoimmune mechanisms with chronic joint inflammation.
- Juvenile Idiopathic Arthritis
- Enthesitis‑Related Arthritis
- Psoriatic Juvenile Arthritis
- Systemic Onset Juvenile Arthritis
- Polyarticular Juvenile Rheumatoid Arthritis
Research aims to refine disease activity metrics and explore biologic agents tailored for the pediatric population.
Systemic Autoimmune Diseases in Children
Focus is placed on multisystem autoimmune conditions that manifest early in life and require interdisciplinary care.
- Systemic Lupus Erythematosus
- Primary Sjögren's Syndrome
- Mixed Connective Tissue Disease
- Dermatomyositis
- Systemic Sclerosis
Clinical studies evaluate targeted immunomodulators and monitor organ‑specific outcomes such as nephritis and myositis.
Rare Autoinflammatory Syndromes
Investigations extend to genetically driven autoinflammatory disorders that often present with recurrent fevers and tissue inflammation.
- Familial Mediterranean Fever
- TRAPS (TNF Receptor‑Associated Periodic Syndrome)
- CAPS (Cryopyrin‑Associated Periodic Syndromes)
- VEXAS Syndrome
- Autoinflammatory Bone Dysplasia
Therapeutic strategies include IL‑1 and IL‑6 blockade, with emphasis on safety in the pediatric setting.
Pediatric Vasculitis and Related Disorders
Work in this area addresses inflammatory vessel diseases that affect children, often with severe systemic involvement.
- ANCA‑Associated Vasculitis
- Kawasaki Disease
- Henoch‑Schönlein Purpura
- Takayasu Arteritis
- Polyarteritis Nodosa
Research evaluates immunosuppressive regimens, biologic agents, and long‑term vascular outcomes.
Emerging Therapeutics in Pediatric Rheumatology
Innovation is directed toward novel biologics, small molecules, and precision‑medicine approaches for refractory disease.
- JAK Inhibitors
- IL‑17/IL‑23 Axis Blockade
- BTK Inhibitors
- Selective B‑Cell Depletion
- Gene‑Therapy Targets for Autoinflammatory Genes
Clinical trials assess efficacy, safety, and biomarker‑guided patient selection across the pediatric rheumatology spectrum.
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