Pavlos M.
- Country
- Greece
- Department
- Clinic of Intensive Care and Pulmonary Diseases
Research Overview
- A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Pharmacokinetics of OMN6 in Patients with Acinetobacter baumannii Complex-Induced HABP or VABP
- Adjunctive Clarithromycin to Prevent Secondary Infections in Patients with Community‑Acquired Pneumonia‑Related Sepsis and Sepsis‑Induced Immunoparalysis (CLASSIFY)
- Evaluation of Emapalumab in Patients with Interferon-Gamma Driven Sepsis: A Randomized, Placebo-Controlled Trial
Data & Insights
Has run more than one trial at 16 of 33 partner sites.
Specializations
Oncology – Advanced Solid Tumors
The investigator leads studies in a broad spectrum of malignant neoplasms, emphasizing targeted and immunologic strategies for late‑stage disease.
- non‑small cell lung cancer
- metastatic colorectal cancer
- urothelial carcinoma
- advanced ovarian cancer
- metastatic castration‑resistant prostate cancer
Research integrates novel checkpoint inhibitors, KRAS‑directed agents, and antibody‑drug conjugates to improve survival outcomes.
Infectious Diseases & Sepsis
Focused on severe bacterial and fungal infections, the investigator evaluates immune‑modulating approaches to reduce mortality.
- sepsis with interferon‑gamma endotype
- candidemia
- hospital‑acquired bacterial pneumonia
- community‑acquired pneumonia‑related sepsis
- severe infections
Efforts target rapid pathogen clearance and mitigation of immunoparalysis in critically ill adults.
Cardiovascular & Heart Failure
Cardiovascular research centers on high‑risk patients with structural and inflammatory cardiac dysfunction.
- heart failure with preserved ejection fraction
- heart failure with mildly reduced ejection fraction
- systemic inflammation in heart failure
- high cardiovascular risk
- hypertension with established cardiovascular disease
Trials assess anti‑inflammatory biologics and novel peptide inhibitors to lower cardiovascular mortality.
Pulmonary & Critical Care
In the intensive care setting, the investigator addresses respiratory failure syndromes and related complications.
- acute respiratory distress syndrome
- ventilator‑associated pneumonia
- severe sepsis‑induced immunoparalysis
- pulmonary hypertension in critical illness
- intensive care unit sepsis management
Interventions aim to restore immune competence and improve pulmonary outcomes in mechanically ventilated patients.
Neuropsychiatric – Psychosis in Alzheimer’s Disease
Research explores therapeutic options for neuropsychiatric manifestations accompanying neurodegeneration.
- psychosis associated with Alzheimer’s disease
- long‑term safety of antipsychotic combinations
- cognitive symptom modulation
- behavioral disturbance management
- neuroinflammatory targeting agents
Studies prioritize efficacy in reducing hallucinations and delusions while preserving cognitive function.
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