Paula C. C.
- Country
- Spain
- Department
- ES10015: Reumatología
Research Overview
- A Phase 3 Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis
- Long-Term Safety, Tolerability, and Efficacy of Zasocitinib in Adults With Active Psoriatic Arthritis: A Phase 3 Extension Study
- Long-Term Safety and Tolerability Assessment of Dapirolizumab Pegol in Patients with Systemic Lupus Erythematosus: A Multicenter, Open-Label Extension Study
Data & Insights
Has run more than one trial at 217 of 395 partner sites.
Specializations
Psoriatic Arthritis and Inflammatory Joint Disease
Clinical research activity includes treatment strategies for active psoriatic arthritis, with attention to patients who are biologic-naïve, biologic-experienced, or stratified by prior biologic use. The portfolio also extends to related axial disease and persistent inflammatory symptoms affecting joint function.
- Psoriatic arthritis
- Axial psoriatic disease
- Biologic-naïve and biologic-experienced inflammatory arthritis
- Knee synovitis
Therapeutic interest centers on interleukin-targeted therapy and other advanced anti-inflammatory approaches aimed at improving control of chronic musculoskeletal inflammation.
Breast Cancer and Hormone Receptor-Driven Oncology
The investigator is extensively involved in studies of early breast cancer, metastatic breast cancer, and high-risk disease subtypes, especially HR-positive and HER2-negative tumors. Research also covers HER2-positive and HER2-low disease, endocrine-resistant disease, and biomarker-defined populations.
- HR-positive / HER2-negative breast cancer
- HER2-positive and HER2-low breast cancer
- Triple-negative breast cancer
- Endocrine-resistant advanced breast cancer
Key therapeutic areas include endocrine therapy, CDK4/6 inhibition, HER2-directed treatment, and emerging combinations for recurrence prevention and metastatic control.
Systemic Autoimmune Disease and Connective Tissue Disorders
Research activity also includes systemic lupus erythematosus, cutaneous lupus erythematosus, and Sjögren’s syndrome, reflecting interest in immune-mediated disease with systemic and mucocutaneous involvement.
- Systemic lupus erythematosus
- Cutaneous lupus erythematosus
- Sjögren’s syndrome
- Autoimmune disease activity
Therapeutic focus includes immune modulation for chronic autoimmune manifestations and symptom burden.
Lung Cancer and Advanced Solid Tumors
The clinical trial portfolio includes non-small cell lung cancer, small cell lung cancer, and advanced solid tumors with brain metastases or leptomeningeal disease. These studies span locally advanced, metastatic, and oligometastatic settings.
- Non-small cell lung cancer
- Squamous and non-squamous lung cancer
- Limited-stage small cell lung cancer
- Brain metastases and leptomeningeal disease
Therapeutic interest is centered on immunotherapy and novel targeted approaches for advanced thoracic malignancies.
Metabolic and Degenerative Joint Conditions
Additional research involvement covers gout with hyperuricemia and osteoarthritis, including erosive inflammatory disease of the hands and knee-related synovitis. These areas reflect interest in chronic pain and crystal-associated or degenerative joint disease.
- Gout with hyperuricemia
- Erosive hand osteoarthritis
- Knee osteoarthritis
- Inflammatory arthropathy
Therapeutic emphasis includes symptom relief, inflammation control, and disease-specific treatment options for musculoskeletal disorders.
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