Paul-Henri W.
- Country
- France
- Department
- Intensive Care
Research Overview
Data & Insights
Has run more than one trial at 0 of 21 partner sites.
Specializations
Cardiovascular Critical Care
Investigator Wicky concentrates on acute cardiac interventions and peri‑operative management in intensive care settings.
- Transcatheter Aortic Valve Implantation
- Coronary Artery Bypass Grafting
- Aortic Bioprosthesis Management
- Frequent Premature Ventricular Complexes
- Post‑operative Atrial Fibrillation Prevention
Research integrates surgical techniques with critical‑care monitoring to improve cardiovascular outcomes.
Gastrointestinal and Hepatobiliary Oncology
His work addresses malignant diseases of the liver, biliary tree, stomach and pancreas.
- Advanced Biliary Tract Cancer
- FGFR2b‑Positive Gastric Adenocarcinoma
- Metastatic Pancreatic Ductal Adenocarcinoma
- Locally Advanced Hepatocellular Carcinoma
- Colorectal Cancer with Microsatellite Instability
Focus includes surgical resections, targeted molecular profiles and adjuvant strategies.
Genitourinary and Prostate Cancer Research
He evaluates therapeutic approaches for malignancies of the prostate, bladder and kidney.
- Metastatic Castration‑Resistant Prostate Cancer
- High‑Risk Muscle‑Invasive Bladder Cancer
- Renal Cell Carcinoma
- Prostate Cancer with PTEN Deficiency
- Neoadjuvant Hormone Therapy in Localized Prostate Cancer
Efforts combine hormonal manipulation, immunomodulation and precision oncology.
Immune‑Based and Molecular Targeted Therapies
He investigates checkpoint inhibition, FGFR inhibition and novel immunotherapeutic combinations.
- PD‑L1 Checkpoint Blockade
- FGFR Inhibitors (e.g., Pemigatinib)
- Dual Durvalumab‑Tremelimumab Regimens
- CAR‑T Cell‑Related Antigen Targeting
- Vaccine‑Induced CD4‑Th1 Responses
Studies aim to match molecular alterations with tailored therapeutic agents.
Infectious and Metabolic Disorders
His portfolio also covers severe infections and metabolic disease management in critical settings.
- Sepsis Antibiotic Strategies
- Mycobacterium avium Complex Pulmonary Therapy
- Type 2 Diabetes Remission after Bariatric Surgery
- Atrial Fibrillation Stroke Prevention
- Antiplatelet Duration after TAVI
Research integrates antimicrobial stewardship with metabolic outcome optimization.
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