Pau L. I.
- Country
- Spain
- Department
- Internal medicine
Research Overview
- Evaluation of Colchicine Efficacy in Reducing NT-proBNP Levels in Patients with Acute Decompensated Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial
- A Randomized, Placebo‑Controlled Trial of Zenagamtide (NNC0487‑0111) in Obese Patients with HFpEF or HFmrEF to Reduce CV Death and HF Hospitalization
- Phase 3 Randomized Study Comparing Asundexian and Apixaban for Stroke Prevention in Atrial Fibrillation Patients at Risk
Data & Insights
Has run more than one trial at 267 of 781 partner sites.
Specializations
Cardiovascular disease
Clinical research activity includes acute coronary syndrome, myocardial infarction, heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, and aortic stenosis, with interest in preventing recurrent major adverse cardiovascular events and managing high-risk cardiometabolic profiles.
- Acute myocardial infarction
- Heart failure with preserved ejection fraction
- Atherosclerotic cardiovascular disease
- Hypertrophic cardiomyopathy
- Pulmonary embolism
Work in this area also extends to lipid disorders, obesity, and vascular risk reduction in patients with complex cardiovascular disease.
Thoracic oncology
Research involvement is strongly centered on non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, and other advanced thoracic malignancies, including molecularly defined disease such as ROS1-positive, ALK-positive, and RET-altered tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- Head and neck squamous cell carcinoma
- Advanced solid tumors
- Brain metastases
Therapeutic interest also includes immunotherapy, targeted treatment, and disease settings with central nervous system involvement or metastatic spread.
Breast and gynecologic oncology
Clinical trial activity covers breast cancer across HER2-positive, HER2-negative, hormone receptor-positive, and triple-negative subtypes, as well as ovarian cancer, endometrial cancer, and cervical cancer.
- Metastatic breast cancer
- Triple-negative breast cancer
- Advanced ovarian cancer
- Endometrial carcinoma
- Cervical cancer
There is also sustained involvement in HER2-directed therapy, endocrine treatment, and management of recurrent or metastatic disease.
Hematologic malignancies
The investigator is engaged in studies of multiple myeloma, lymphoma, leukemia, and myeloproliferative neoplasms, including acute myeloid leukemia, chronic lymphocytic leukemia, follicular lymphoma, and mantle cell lymphoma.
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Myelofibrosis
Therapeutic focus includes cellular therapy, immune-based treatment, and approaches for relapsed or refractory blood cancers.
Immune-mediated and systemic disease
Research interests also include systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, myasthenia gravis, thyroid eye disease, and other autoimmune disorders affecting skin, joints, muscle, and the nervous system.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Myasthenia gravis
- Thyroid eye disease
- Inflammatory myopathy
Additional activity spans inflammatory bowel disease, vasculitis-related conditions, and allergic disease, reflecting broad therapeutic involvement in immune dysregulation.
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