Ondrej V.
- Country
- Czechia
- Department
- Transplantcentrum, Klinika nefrologie
Research Overview
- Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of Efgartigimod Alfa SC in Antibody-Mediated Rejection in Kidney Transplant Recipients
- Efficacy and Safety of Intravenous Ravulizumab in Reducing Delayed Graft Function in High-Risk Adult Kidney Transplant Recipients: A Phase 3 Randomized Study
Data & Insights
Has run more than one trial at 6 of 44 partner sites.
Specializations
Kidney Transplantation and Allograft Immunology
Clinical research in kidney transplantation with attention to antibody-mediated rejection, late isolated microvascular inflammation, post-transplant graft function, and outcomes in highly sensitised patients. Interest also extends to immunosuppressive strategies and transplant-related complications.
- Antibody-mediated rejection
- Kidney transplant rejection
- Delayed graft function
- Highly sensitised kidney transplant recipients
Work also covers simultaneous pancreas and kidney transplantation and long-term post-transplant monitoring.
Chronic Kidney Disease and Glomerular Disorders
Research activity includes chronic kidney disease, IgA nephropathy, C3 glomerulopathy, immune complex membranoproliferative glomerulonephritis, rapidly progressive glomerulonephritis, and Alport syndrome. The therapeutic focus spans preservation of renal function and control of immune-mediated kidney injury.
- IgA nephropathy
- C3 glomerulopathy
- Rapidly progressive glomerulonephritis
- Alport syndrome
Additional interest includes anemia in dialysis, end-stage kidney disease, and CKD progression.
Cardiovascular Disease and Heart Failure
Clinical interests include acute myocardial infarction, acute coronary syndrome, heart failure, heart failure with preserved or reduced ejection fraction, cardiogenic shock, atrial fibrillation, and atherosclerotic cardiovascular disease. The portfolio also includes therapies aimed at reducing recurrent ischemic and thromboembolic risk.
- Acute myocardial infarction
- Heart failure
- Cardiogenic shock
- Atrial fibrillation
Work further extends to pulmonary hypertension due to left heart disease, calcific aortic valve stenosis, and hypertrophic cardiomyopathy.
Metabolic Disease, Lipid Disorders, and Diabetes
Research includes type 1 diabetes, type 2 diabetes, obesity, metabolic syndrome, hypercholesterolemia, hypertriglyceridemia, and familial hypercholesterolemia. Therapeutic interests also cover metabolic control in diabetes-related complications and cardiovascular risk reduction.
- Type 1 diabetes
- Type 2 diabetes
- Hypertriglyceridemia
- Heterozygous familial hypercholesterolaemia
Additional focus includes diabetic retinopathy, diabetic foot infections, and weight management.
Immune-Mediated, Hepatic, and Pulmonary Conditions
Clinical interests also include Crohn’s disease, ulcerative colitis, primary biliary cholangitis, alpha-1 antitrypsin deficiency-associated liver disease, pulmonary arterial hypertension, and transthyretin amyloid cardiomyopathy. This reflects involvement across inflammatory, hepatic, and infiltrative cardiovascular diseases.
- Crohn’s disease
- Ulcerative colitis
- Primary biliary cholangitis
- Pulmonary arterial hypertension
Research also encompasses amyloid cardiomyopathy, protoporphyria, and chronic hepatitis D infection.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.