Olivier D.
- Country
- France
- Department
- Neurology
Research Overview
- Tenecteplase plus Thrombectomy versus Thrombectomy Alone in Patients with Large Core Ischemic Stroke: A Multicentre Randomized Controlled Trial
- Efficacy of prophylactic levetiracetam on functional outcomes in patients with acute intracerebral haemorrhage: a phase 3, randomised, double-blind, placebo-controlled trial
- Efficacy of Apixaban Versus Standard Care in Patients with Intracerebral Hemorrhage: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 30 of 110 partner sites.
Specializations
Neurological Disorders
Clinical activity in neurology spans multiple sclerosis, Parkinson’s disease, focal epilepsy, migraine, and movement disorders such as Tourette’s disorder and cervical dystonia. The portfolio also includes studies in stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and brain trauma.
- Multiple sclerosis
- Parkinson’s disease
- Stroke
- Epilepsy
- Tourette’s disorder
Interest also extends to neuroimmunology and neurocognitive disorders, with attention to therapeutic options for chronic and progressive neurological disease.
Haematology and Blood Cancers
Research involvement is strong in acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, myelodysplastic syndromes, and myelofibrosis. The clinical landscape also includes multiple myeloma, lymphomas, and myeloid malignancies.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
- Myelodysplastic syndromes
- Lymphoma
Therapeutic interests include immunotherapy, targeted therapy, and stem cell transplantation across relapsed, refractory, and newly diagnosed haematologic disease.
Respiratory and Critical Care Medicine
Clinical trial involvement covers asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, interstitial lung disease, and pulmonary hypertension. The portfolio also includes severe pneumonia, influenza, and ventilator-associated pneumonia in acute care settings.
- Asthma
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Pulmonary hypertension
- Critical care infections
Therapeutic focus includes airway inflammation, fibrotic lung disease, and management of respiratory failure in hospital and intensive care environments.
Cardiovascular and Renal Medicine
Research activity includes atherosclerotic cardiovascular disease, myocardial infarction, heart failure, atrial fibrillation, and hypertension. Renal interests include chronic kidney disease, IgA nephropathy, glomerular disease, and kidney transplantation.
- Heart failure
- Myocardial infarction
- Chronic kidney disease
- IgA nephropathy
- Kidney transplantation
Therapeutic domains also include cardiovascular prevention, thromboembolic disease, and transplant rejection.
Autoimmune, Inflammatory, and Gastroenterological Disease
Clinical interests extend to rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, Sjögren’s syndrome, vasculitis, ulcerative colitis, and Crohn’s disease. The portfolio also includes primary biliary cholangitis, primary sclerosing cholangitis, and hepatocellular carcinoma in liver-related disease.
- Rheumatoid arthritis
- Systemic sclerosis
- Sjögren’s syndrome
- Inflammatory bowel disease
- Vasculitis
Therapeutic emphasis includes immune modulation, anti-inflammatory treatment, and management of chronic autoimmune organ involvement.
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