Octavian V.
- Country
- Romania
- Department
- Psihiatrie
Research Overview
- Open-Label Long-Term Safety and Tolerability of ML-007C-MA (fesoterodine) in Adults with Hallucinations and Delusions of Alzheimer’s Disease Psychosis
- Evaluation of Sunobinop Tosilate on Alcohol Consumption and Craving in Patients with Moderate to Severe Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Study
- Efficacy and Safety Evaluation of ITI-1284 in Psychosis Associated with Alzheimer's Disease: A Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 124 of 211 partner sites.
Specializations
Neuropsychiatric disorders
Clinical research activity includes Alzheimer’s disease and related behavioral and psychotic symptoms, with attention to agitation, hallucinations, delusions, and psychosis. The portfolio also extends to bipolar I disorder, major depressive disorder, stress, and alcohol use disorder.
- Alzheimer’s disease psychosis
- Agitation and hallucinations
- Bipolar mania
- Depressive disorders
Interest also includes neurobehavioral symptom control in cognitive decline and psychiatric symptom management in chronic neurologic disease.
Thoracic and upper gastrointestinal oncology
Research involvement is strongly centered on non-small cell lung cancer, small-cell lung cancer, melanoma, and advanced cancers of the esophagus, stomach, and gastroesophageal junction. The oncology portfolio also includes biliary tract cancer, colorectal cancer, pancreatic cancer, and breast cancer.
- Advanced lung cancer
- Gastric and gastroesophageal cancers
- Melanoma
- Breast cancer
Therapeutic interest emphasizes biomarker-defined malignancies, including KRAS G12C, EGFR-mutated, HER2-positive, and PD-L1-expressing tumors.
Autoimmune and inflammatory disease
Clinical trial activity covers ulcerative colitis, Crohn’s disease, plaque psoriasis, cutaneous lupus erythematosus, Sjögren’s syndrome, atopic dermatitis, chronic inducible urticaria, hidradenitis suppurativa, and thyroid eye disease.
- Inflammatory bowel disease
- Psoriasis
- Systemic autoimmune disease
- Dermatologic inflammation
Therapeutic interest also extends to immune-mediated skin and mucosal disorders requiring targeted anti-inflammatory treatment.
Hepatology and gastrointestinal disease
Research involvement includes non-alcoholic steatohepatitis, metabolic dysfunction-associated steatotic liver disease, hepatocellular carcinoma, cholangiocarcinoma, cirrhosis, portal hypertension, and chronic hepatitis B. Gastrointestinal disorders such as ulcerative colitis and Crohn’s disease are also represented within this domain.
- Fatty liver disease
- Cirrhosis and portal hypertension
- Hepatobiliary cancer
- Chronic viral liver disease
Interest includes both inflammatory liver disease and advanced hepatobiliary malignancy, with a focus on therapeutic options for progressive liver-related conditions.
Cardiometabolic, renal, and endocrine disorders
Clinical research activity spans heart failure, acute coronary syndrome, myocardial infarction, cancer-associated thrombosis, diabetic retinopathy, congenital adrenal hyperplasia, Cushing syndrome, hereditary hemochromatosis, urinary tract infection, and urinary incontinence.
- Heart failure and cardiovascular risk
- Thrombotic prevention
- Endocrine disorders
- Ophthalmic complications of diabetes
Therapeutic focus also includes kidney function impairment, bleeding prevention, and treatment strategies for complex cardiometabolic disease.
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