Nikolay C.
- Country
- Bulgaria
- Department
- Medical Oncology Clinic
Research Overview
- Phase 3 Randomized Study of Gedatolisib Combination Therapy versus Standard Endocrine Therapy in HR‑Positive, HER2‑Negative Advanced Breast Cancer Post‑CDK4/6 Inhibitor
- Phase 3 Randomized Study of Telisotuzumab Vedotin vs. Docetaxel in c-Met Overexpressing EGFR Wildtype Non-Squamous NSCLC
- Phase 2 Study of Sequential THIO and Cemiplimab in Advanced Non-Small Cell Lung Cancer
Data & Insights
Has run more than one trial at 61 of 279 partner sites.
Specializations
Cardiovascular and renal medicine
The clinical research profile includes prevention and treatment of atherosclerotic cardiovascular disease, heart failure, hypertension, hypercholesterolemia, and acute myocardial infarction, together with studies in chronic kidney disease, systemic inflammation, and cardiorenal risk reduction.
- Major adverse cardiovascular events
- Heart failure with preserved or mildly reduced ejection fraction
- Primary prevention of ASCVD
- Chronic kidney disease and hypertension
Therapeutic interests also extend to obesity-related cardiometabolic disease and interventions targeting inflammation as part of cardiovascular risk management.
Thoracic and solid tumor oncology
Active involvement in non-small cell lung cancer, including advanced, metastatic, and HER2- or c-Met-driven disease, as well as urothelial cancer and colorectal cancer, reflects a strong focus on contemporary solid tumor therapy.
- Advanced non-small cell lung cancer
- Metastatic urothelial cancer
- Colorectal cancer with cachexia
- Targeted therapy in biomarker-defined tumors
Research activity also includes combinations with immunotherapy and other targeted anticancer approaches in advanced malignancies.
Hematologic malignancies and blood disorders
The investigator is involved in studies of chronic lymphocytic leukemia, chronic myeloid leukemia, diffuse large B-cell lymphoma, myelofibrosis, and myelodysplastic neoplasms, alongside nonmalignant hematologic conditions such as immune thrombocytopenia.
- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- Chronic myeloid leukemia
- Myelofibrosis
- Immune thrombocytopenia
Additional interest is seen in therapies addressing transfusion-dependent anemia and relapsed or refractory hematologic disease.
Autoimmune, inflammatory, and gastrointestinal disease
Research spans multiple sclerosis, systemic lupus erythematosus, Sjögren's disease, Crohn's disease, and ulcerative colitis, indicating sustained interest in immune-mediated disorders across neurologic, rheumatologic, and gastrointestinal domains.
- Relapsing and progressive multiple sclerosis
- Systemic lupus erythematosus
- Sjögren's disease
- Crohn's disease and ulcerative colitis
Therapeutic work also includes targeted immunomodulation in pediatric and adult inflammatory disease.
Metabolic, endocrine, and infectious conditions
The clinical landscape also covers type 2 diabetes, obesity, congenital hyperinsulinism, growth disorders, and chronic hepatitis delta, with additional work in complicated urinary tract infection and acute pyelonephritis.
- Type 2 diabetes and obesity
- Congenital hyperinsulinism
- Pediatric growth disorders
- Chronic hepatitis delta infection
This portfolio also includes therapeutic interest in metabolic risk reduction and anti-infective treatment for hospitalized adult patients.
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