Nicola U.
- Country
- Italy
- Department
- Rheumatology division, Department of Polyspecialistic medicines
Research Overview
Data & Insights
Has run more than one trial at 0 of 14 partner sites.
Specializations
Rheumatology and Autoimmune Disorders
The investigator’s work centers on inflammatory joint disease and systemic autoimmunity, addressing conditions such as Rheumatoid Arthritis and Systemic Lupus Erythematosus.
- Moderate to severe rheumatoid arthritis
- Chronic inducible urticaria (CINDU)
- Severe asthma with eosinophilic phenotype
- Severe refractory idiopathic inflammatory myopathies
Therapeutic exploration includes biologic and targeted agents that modify pathogenic immune pathways.
Cardiovascular and Metabolic Medicine
Focus is placed on atherosclerotic disease and related risk factors, including Atherosclerotic Cardiovascular Disease (ASCVD), Hypertension, and Atrial Fibrillation.
- Primary prevention of ASCVD
- Elevated lipoprotein(a) management
- Heart failure with reduced ejection fraction
- High‑risk hypertriglyceridemia
Research aims to reduce major adverse cardiovascular events through lipid‑lowering and anti‑arrhythmic strategies.
Oncology – Solid Tumors
Clinical investigations span a broad spectrum of solid malignancies, notably Non‑Small Cell Lung Cancer, Colorectal Cancer, and Hepatocellular Carcinoma.
- KRAS‑mutant NSCLC and colorectal cancer
- HER2‑positive gastric and gastroesophageal junction adenocarcinoma
- Advanced pancreatic ductal adenocarcinoma
- Metastatic breast cancer with HR+/HER2‑negative phenotype
Efforts emphasize targeted therapies and combination regimens to improve progression‑free survival.
Oncology – Hematologic Malignancies
The investigator engages in studies of blood cancers, including Acute Myeloid Leukemia and various B‑cell lymphomas.
- Relapsed/refractory follicular lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma post‑autologous transplant
- Acute lymphoblastic leukemia, Philadelphia‑negative
Therapeutic goals involve novel agents that target genetic and microenvironmental drivers of malignancy.
Hepatology and Liver Disease
Research addresses chronic liver conditions such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, and non‑alcoholic steatohepatitis (NASH).
- Pruritus associated with PBC and PSC
- Compensated cirrhosis with portal hypertension
- Alcohol‑related liver disease
- Metabolic dysfunction‑associated steatohepatitis
Investigations target symptom relief and disease‑modifying pathways to halt fibrosis progression.
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