Elizabeth D. K.
- Country
- The Netherlands
- Department
- Hematology
Research Overview
- A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy C – Relapsed/Refractory Burkitt Lymphoma (BL)
- Phase 2 Randomized Double‑Blind Study of Subcutaneous ALN‑6400 in Women with Von Willebrand Disease and Heavy Menstrual Bleeding
- Long-Term Follow-Up Study of Idecabtagene Vicleucel and Lisocabtagene Maraleucel in Patients Previously Treated with Gene-Modified T Cells
Data & Insights
Has run more than one trial at 159 of 273 partner sites.
Specializations
Hematologic Malignancies
Clinical research activity includes a strong focus on acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma, and relapsed or refractory B-cell lymphomas, alongside other advanced blood cancers and aggressive lymphoid neoplasms.
- Acute myeloid leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Relapsed/refractory B-cell malignancies
Work in this area also extends to rare lymphoma subtypes, including Waldenström macroglobulinemia, Burkitt lymphoma, and hairy cell leukemia.
Gastrointestinal and Hepatobiliary Disease
The investigator is involved in trials across inflammatory bowel disease, Crohn’s disease, ulcerative colitis, and broader gastrointestinal inflammatory disorders, with additional interest in liver-related conditions.
- Crohn’s disease
- Ulcerative colitis
- Primary sclerosing cholangitis
- Polycystic liver disease
Research activity also covers gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma, and other advanced gastrointestinal tumours.
Autoimmune and Renal Disorders
Another major area of interest is immune-mediated disease, especially IgA nephropathy, complement-mediated glomerulopathy, anti-GBM antibody disease, and systemic sclerosis.
- IgA nephropathy
- C3 glomerulopathy
- Anti-GBM antibody disease
- Systemic sclerosis
Additional involvement includes rheumatoid arthritis, lupus nephritis, focal segmental glomerulosclerosis, and other proteinuric kidney diseases.
Cardiovascular Medicine
Clinical trial participation spans atherosclerotic cardiovascular disease, myocardial infarction, atrial fibrillation, and heart failure, with a particular emphasis on prevention and risk reduction.
- Atherosclerotic cardiovascular disease
- Myocardial infarction
- Atrial fibrillation
- Heart failure
Research also includes resistant hypertension, hypercholesterolemia, lipoprotein(a)-related risk, and coronary artery disease.
Solid Tumors and Rare Oncology
The investigator is active in studies of urothelial carcinoma, prostate cancer, non-small cell lung cancer, renal cell carcinoma, and head and neck squamous cell carcinoma.
- Urothelial carcinoma
- Prostate cancer
- Non-small cell lung cancer
- Renal cell carcinoma
Additional oncologic interests include melanoma, ovarian cancer, bladder cancer, and gastrointestinal stromal tumour.
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