Nick B.
- Country
- The Netherlands
- Department
- Medical Oncology
Research Overview
- A Phase I/II Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of AZD9750 as Monotherapy and in Combination Therapy in Participants with Metastatic Prostate Cancer
- Phase 3 Open-Label Comparison of Ifinatamab Deruxtecan and Docetaxel in Metastatic Castration-Resistant Prostate Cancer
- A Phase 3 Randomized, Double-blind, Placebo-controlled Study of JNJ-78278343, a T-cell-redirecting Agent Targeting Human Kallikrein 2 Versus Placebo for Metastatic Castration-resistant Prostate Cancer
Data & Insights
Has run more than one trial at 46 of 163 partner sites.
Specializations
Thoracic Oncology
The clinical research profile includes a strong focus on non-small cell lung cancer, small-cell lung cancer, and other advanced thoracic malignancies, with interest in precision-matched treatment strategies and perioperative cancer care.
- Advanced and resectable non-small cell lung cancer
- Small-cell lung cancer
- EGFR-mutated and KRAS G12C-mutant lung cancer
- Malignant pleural and mediastinal disease
Research activity also extends to immunotherapy-based approaches and targeted treatment development in lung cancer.
Genitourinary and Gastrointestinal Cancer
Another major area of interest is urothelial carcinoma, bladder cancer, prostate cancer, pancreatic cancer, and colorectal cancer, including locally advanced, metastatic, and perioperative settings.
- Muscle-invasive and non-muscle invasive bladder cancer
- Metastatic prostate cancer
- Borderline resectable and metastatic pancreatic cancer
- Colorectal and rectal cancer
These studies reflect sustained involvement in treatment innovation across genitourinary and gastrointestinal oncology.
Hematologic Malignancies
The investigator is actively involved in research on lymphoma, multiple myeloma, acute myeloid leukemia, and related high-risk blood cancers, with attention to relapsed, refractory, and transplant-related disease.
- Diffuse large B-cell lymphoma
- Mantle cell lymphoma and other B-cell lymphomas
- Relapsed and refractory multiple myeloma
- Acute myeloid leukemia and myelodysplastic syndromes
Work in this domain includes evaluation of cellular therapy, immunotherapy, and other advanced hematology treatments.
Immune-Mediated and Inflammatory Disorders
Clinical interests also cover atopic dermatitis, hidradenitis suppurativa, Crohn's disease, ulcerative colitis, and other immune-driven conditions affecting skin and the gastrointestinal tract.
- Atopic dermatitis and atopic eczema
- Hidradenitis suppurativa
- Crohn's disease and ulcerative colitis
- Primary biliary cholangitis and primary sclerosing cholangitis
This area includes therapeutic development in immune-mediated inflammatory disease and chronic inflammatory syndromes.
Rare Disease, Cardio-Renal, and Pulmonary Medicine
The research portfolio further spans cystic fibrosis, Pompe disease, cardiomyopathy, heart failure, chronic kidney disease, and interstitial lung disease, alongside selected rare immune and metabolic disorders.
- Cystic fibrosis and pulmonary fibrosis
- Pompe disease and other inherited metabolic disorders
- Heart failure and cardiomyopathy
- Chronic kidney disease and transplant-related conditions
These trials support therapeutic innovation in rare disease, cardiovascular medicine, nephrology, and pulmonology.
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