Nathalie O. G.
- Country
- France
- Department
- Medical Oncology
Research Overview
- Phase II Study of Ficerafusp Alfa and Nivolumab in Patients with Platinum-Refractory Head and Neck Squamous Cell Carcinoma Progressing Within 6 Months of Multimodal Therapy
- Phase 2 Trial of Pucotenlimab and Becotatug Vedotin Induction Therapy Versus Becotatug Vedotin Alone in Locally Advanced Head and Neck Squamous Cell Carcinoma
Data & Insights
Has run more than one trial at 6 of 25 partner sites.
Specializations
Haematological malignancies
Clinical research activity is centred on acute leukaemias, myelodysplastic syndromes, and myeloid neoplasms, with additional interest in chronic lymphocytic leukaemia, mantle cell lymphoma, and other aggressive non-Hodgkin lymphomas.
- Acute myeloid leukaemia
- Myelodysplastic syndromes
- Chronic lymphocytic leukaemia
- Diffuse large B-cell lymphoma
- Peripheral T-cell lymphoma
Research interests also extend to allogeneic stem cell transplantation, minimal residual disease, and treatment strategies for relapsed or refractory haematologic disease.
Breast cancer and molecularly defined solid tumours
The investigator is involved in studies of breast cancer across early, locally advanced, and metastatic settings, especially hormone receptor-positive, HER2-negative, HER2-positive, and triple-negative breast cancer.
- Hormone receptor-positive breast cancer
- HER2-negative metastatic breast cancer
- Triple-negative breast cancer
- HER2-positive breast cancer
- Circulating tumour DNA
Therapeutic interest includes endocrine therapy, CDK4/6 inhibition, PARP inhibition, and biomarker-driven treatment selection in advanced disease.
Lymphoid and plasma cell disorders
Her clinical portfolio includes follicular lymphoma, marginal zone lymphoma, Waldenström macroglobulinemia, multiple myeloma, and primary central nervous system lymphoma.
- Follicular lymphoma
- Marginal zone lymphoma
- Waldenström macroglobulinemia
- Multiple myeloma
- Primary central nervous system lymphoma
Research activity also covers bispecific antibodies, BTK-targeted therapy, and treatment options for relapsed or refractory B-cell malignancies.
Head and neck, lung, and central nervous system cancers
The investigator is active in trials for head and neck squamous cell carcinoma, non-small cell lung cancer, and glioblastoma, including advanced and recurrent presentations.
- Head and neck squamous cell carcinoma
- Non-small cell lung cancer
- Glioblastoma
- Brainstem gliomas
- Central nervous system lymphoma
Work in these areas reflects interest in immunotherapy, targeted anticancer treatment, and management of difficult-to-treat solid tumours.
Genitourinary, gynaecologic, and gastrointestinal oncology
Her research landscape also includes prostate cancer, ovarian cancer, endometrial cancer, cervical cancer, and colorectal cancer, with attention to both localized and metastatic disease.
- Prostate cancer
- Ovarian cancer
- Endometrial cancer
- Cervical cancer
- Colorectal cancer
These studies involve precision oncology, radionuclide therapy, and treatment approaches for recurrent or high-risk disease.
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