Nakul M.
- Country
- Germany
- Department
- na
Research Overview
- Evaluation of GSK3862995B in Healthy Subjects and Patients with Chronic Obstructive Pulmonary Disease
- Phase 1b Double‑Blind Single‑Dose Study of ATI‑052 Assessing Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy in Adults with Mild‑to‑Moderate Asthma
- Phase 3 Study of GB-0895 Adjunctive Therapy in Adults and Adolescents with Severe Uncontrolled Asthma
Data & Insights
Has run more than one trial at 290 of 850 partner sites.
Specializations
Respiratory medicine and airway inflammation
Clinical research activity is centered on asthma, chronic obstructive pulmonary disease, bronchiectasis, chronic cough, and progressive pulmonary fibrosis, with additional interest in idiopathic pulmonary fibrosis and other interstitial lung diseases.
- Severe asthma
- COPD and chronic bronchitis
- Bronchiectasis and refractory cough
- Fibrotic lung disease
The therapeutic scope includes biologic and inhaled approaches for uncontrolled airway disease, symptom burden, and exacerbation prevention.
Cardiovascular disease and metabolic risk
Investigator involvement extends across heart failure, atherosclerotic cardiovascular disease, hypertension, hyperlipidemia, elevated lipoprotein(a), and broader cardiovascular risk reduction.
- Heart failure across preserved and reduced ejection fraction phenotypes
- Atherosclerotic cardiovascular disease
- Lipoprotein(a) and lipid lowering
- Hypertension with established cardiovascular disease
Research activity also includes therapies aimed at reducing major cardiovascular events and improving cardiometabolic outcomes in high-risk adults.
Allergic and eosinophilic disease
There is a strong therapeutic focus on type 2 inflammation across atopic dermatitis, eosinophilic asthma, and allergic asthma, with related work in uncontrolled and exacerbation-prone airway disease.
- Atopic dermatitis
- Eosinophilic asthma
- Uncontrolled asthma with type 2 inflammation
- Biologic therapies targeting inflammatory pathways
The portfolio reflects interest in immune-mediated disorders where modulation of inflammatory signaling is central to treatment development.
Neurology, sleep, and mental health
Clinical interests include major depressive disorder, insomnia disorder, Parkinson's disease, migraine, and cognitive impairment associated with post-COVID-19 syndrome.
- Depressive disorders
- Sleep disturbance
- Neurocognitive impairment
- Migraine and Parkinson's disease
The therapeutic landscape spans symptom control, functional improvement, and management of persistent neuropsychiatric burden.
Gastroenterology, endocrinology, and musculoskeletal pain
Additional trial involvement covers non-alcoholic steatohepatitis, type 2 diabetes mellitus, obesity, irritable bowel syndrome, osteoarthritis, and neuropathic pain.
- NASH and metabolic liver disease
- Type 2 diabetes with obesity
- IBS-D and gastrointestinal symptoms
- Knee osteoarthritis and diabetic neuropathic pain
These studies reflect therapeutic interest in chronic metabolic, digestive, and pain-related conditions with substantial unmet clinical need.
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