Moises D. M.
- Country
- Spain
- Department
- Servicio de Aparato Digestivo
Research Overview
- A Phase IIa, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacodynamics of AZD4831 in Participants with Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) with Fibrosis
- Efficacy and Safety Evaluation of Bepirovirsen in HBeAg-Negative Nucleos(t)ide Analogue-Treated Patients with Chronic Hepatitis B: A Phase 3 Randomized Study
- Phase 2 Open-Label Evaluation of Bemnifosbuvir Hemisulfate and Ruzasvir for Safety and Efficacy in Chronic Hepatitis C Virus Infection
Data & Insights
Has run more than one trial at 7 of 89 partner sites.
Specializations
Hepatology and chronic liver disease
Clinical research activity is centered on hepatology, with interest in non-alcoholic steatohepatitis, alcohol-related liver disease, and broader liver disease management. The trial portfolio also includes advanced liver complications and viral liver infections.
- Non-alcoholic steatohepatitis
- Alcohol-related liver disease
- Hepatocellular carcinoma
- Chronic hepatitis B and hepatitis C
- Hepatic encephalopathy
Work in this area also extends to primary biliary cholangitis, chronic hepatitis D, and liver-related oncology, reflecting a strong therapeutic focus on progressive and treatment-relevant hepatic disorders.
Gastrointestinal oncology and liver-directed cancer care
The investigator is involved in therapeutic studies across colorectal cancer, gastric cancer, pancreatic cancer, and biliary tract cancer, with particular attention to advanced and metastatic disease. The portfolio includes malignancies where systemic treatment selection is central to care.
- Colorectal cancer
- Gastric adenocarcinoma
- Pancreatic cancer
- Cholangiocarcinoma
- Hepatocellular carcinoma
Research interests also cover biomarker-defined and unresectable tumors, including KRAS G12C-mutant disease and microsatellite instability-high colorectal cancer.
Thoracic oncology and head and neck cancer
Another major area of activity is lung cancer, spanning non-small cell lung cancer and small cell lung cancer in both resectable and metastatic settings. The investigator also participates in studies of head and neck squamous cell carcinoma and related recurrent disease.
- Non-small cell lung cancer
- Small cell lung cancer
- Metastatic lung cancer
- Head and neck squamous cell carcinoma
- HPV-16 positive recurrent or metastatic malignancies
This area includes interest in postoperative, recurrent, and advanced disease states, along with molecularly selected thoracic tumors.
Melanoma and other solid tumors
The clinical portfolio includes extensive involvement in melanoma, including cutaneous, metastatic, unresectable, and uveal forms. Related research also covers other advanced solid tumors and biomarker-driven cancers.
- Cutaneous melanoma
- Metastatic uveal melanoma
- Advanced solid tumors
- Renal cell carcinoma
- Urothelial carcinoma
Therapeutic interest also extends to triple-negative breast cancer, prostate cancer, and ovarian cancer, indicating broad engagement with difficult-to-treat oncologic settings.
Immune-mediated, metabolic, and cardiovascular disorders
The investigator also contributes to studies in atopic dermatitis, psoriasis, systemic lupus erythematosus, and hidradenitis suppurativa, alongside metabolic and cardiovascular conditions such as obesity, diabetes mellitus, and atherosclerotic cardiovascular disease.
- Atopic dermatitis
- Psoriasis
- Systemic lupus erythematosus
- Obesity and diabetes mellitus
- Atrial fibrillation and heart failure
Additional interest includes viral hepatitis, HIV infection, and cardiovascular prevention, reflecting a therapeutic range beyond liver disease and oncology.
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