Miguel S.
- Country
- Portugal
- Department
- BlueClinical Phase I
Research Overview
Data & Insights
Has run more than one trial at 0 of 3 partner sites.
Specializations
Oncology
The investigator focuses on therapeutic development for refractory solid tumours and haematologic malignancies such as advanced or recurrent endometrial carcinoma, unresectable hepatocellular carcinoma, and radioiodine‑refractory differentiated thyroid carcinoma.
- Endometrial carcinoma
- Hepatocellular carcinoma
- Thyroid carcinoma
- Chronic myelogenous leukemia
- Philadelphia‑chromosome positive leukemia
Therapeutic efforts target disease progression after standard platinum‑based regimens and aim to introduce novel targeted or immunologic agents.
Metabolic & Endocrine Disorders
Clinical work includes studies on metabolic dysregulation and hormonal insufficiency, notably type 2 diabetes mellitus and male hypogonadism, with attention to glycaemic control and androgen replacement strategies.
- Type 2 diabetes
- Male hypogonadism
- Testosterone deficiency
- Glucose‑lowering agents
- Hormone replacement therapy
Research emphasizes improving metabolic outcomes and quality of life through innovative pharmacologic formulations.
Immunology & Hematology
The investigator addresses immune‑mediated and hematologic conditions, including aplastic anemia, thrombocytopenia, and autoimmune neuroinflammation such as multiple sclerosis.
- Aplastic anemia
- Thrombocytopenia
- Multiple sclerosis
- Immune‑modulating therapies
- Hematopoietic support agents
Efforts aim to restore normal blood cell production and modulate pathogenic immune pathways.
Respiratory & Allergic Diseases
Research activities include evaluation of treatments for allergic and urticarial conditions, such as allergic rhinitis and urticaria, focusing on symptom relief and immune tolerance.
- Allergic rhinitis
- Urticaria
- Antihistamine efficacy
- Anti‑inflammatory formulations
- Allergen desensitization
Therapeutic development targets rapid onset of action and sustained control of hypersensitivity reactions.
Neuropsychiatric & Addiction
Clinical investigations cover central nervous system disorders, including schizophrenia and substance dependence such as nicotine addiction, exploring pharmacologic modulation of neurotransmission.
- Schizophrenia
- Nicotine addiction
- Antipsychotic agents
- Smoking cessation therapies
- Neurocognitive outcomes
Focus lies on improving symptom management and reducing dependence through novel drug delivery systems.
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