michel L. M.
- Country
- France
- Department
- Evaluation de la douleur
Research Overview
- Long-Term Safety and Tolerability of Atogepant for Migraine Prevention in Chronic or Episodic Migraine: A Phase 3, 156-Week Extension Study
- Efficacy of Amiloride Hydrochloride Dihydrate in Prophylaxis of Migraine with Aura: A Proof-of-Concept Study
- Efficacy of Eptinezumab as Adjunctive Therapy in Preventing Migraine and Treating Medication Overuse Headache in Patients with Dual Diagnosis
Data & Insights
Has run more than one trial at 48 of 165 partner sites.
Specializations
Pain Evaluation and Symptom Management
The investigator is centered on pain assessment and therapeutic strategies for difficult-to-control symptoms, with activity spanning acute pain, chronic migraine, medication-overuse headache, and severe pain syndromes. This includes interest in functional improvement and relief of persistent discomfort across neurological, musculoskeletal, and inflammatory conditions.
- Chronic migraine
- Medication-overuse headache
- Acute low back pain
- Severe acute pain
- Bowel urgency
Therapeutic interest also extends to interventions addressing pain-related disability in osteoarthritis and other symptomatic disorders managed within hospital-based care.
Autoimmune and Inflammatory Diseases
Clinical research activity includes a broad focus on immune-mediated disorders affecting the skin, joints, bowel, and systemic connective tissue. The investigator is involved in studies of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, and systemic sclerosis.
- Rheumatoid arthritis
- Psoriatic arthritis
- Ulcerative colitis
- Crohn's disease
- Systemic sclerosis
Additional therapeutic interest is seen in alopecia areata, atopic dermatitis, hidradenitis suppurativa, vitiligo, and bullous pemphigoid, reflecting engagement with chronic inflammatory and dermatologic immune disorders.
Neurology and Neuroimmunology
The investigator contributes to research in neurological disease areas that include multiple sclerosis, myasthenia gravis, amyotrophic lateral sclerosis, Parkinson's disease, and chronic inflammatory demyelinating polyneuropathy. These interests cover both degenerative and immune-mediated neurologic conditions.
- Multiple sclerosis
- Myasthenia gravis
- Amyotrophic lateral sclerosis
- Parkinson's disease
- Chronic inflammatory demyelinating polyradiculoneuropathy
Research activity also includes migraine aura, essential tremor, and upper limb spasticity, supporting a therapeutic profile that spans movement disorders, neuromuscular disease, and disability-related neurological symptoms.
Hematology and Oncology
The investigator is active in malignancies and blood disorders, with emphasis on acute myeloid leukemia, myelodysplastic syndromes, multiple myeloma, lymphoma, and melanoma. This portfolio reflects involvement in both hematologic cancers and solid tumors requiring advanced systemic treatment approaches.
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Melanoma
Further interest is present in acute lymphoblastic leukemia, myelofibrosis, marginal zone lymphoma, and cutaneous squamous cell carcinoma, indicating a sustained role in innovative cancer therapeutics and hematologic disease management.
Cardiometabolic, Renal, and Infectious Diseases
Clinical trial involvement also covers cardiometabolic and organ-specific disease domains, including atherosclerotic cardiovascular disease, myocardial infarction, heart failure, chronic kidney disease, and type 2 diabetes. These areas indicate interest in vascular risk reduction and chronic organ protection.
- Atherosclerotic cardiovascular disease
- Acute myocardial infarction
- Chronic kidney disease
- Type 2 diabetes
- Prosthetic joint infections
Additional therapeutic domains include hepatocellular carcinoma, non-alcoholic steatohepatitis, pulmonary arterial hypertension, and prosthetic joint infection, showing engagement across metabolic, hepatic, pulmonary vascular, and infectious conditions.
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