Michaela Z.
- Country
- Czechia
- Department
- Onkologické oddělení
Research Overview
- Palazestrant and Ribociclib versus Letrozole and Ribociclib for First-line Treatment of ER+/HER2- Advanced Breast Cancer
- A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients With Hormone Receptor-Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2−) (HER2 IHC0 or HER2-low [IHC 1+, IHC 2+/ISH−]) Inoperable, Locally Advanced, or Metastatic Breast Cancer and Have Received Endocrine Therapy
- Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Elacestrant and Everolimus in ER+/HER2-, ESR1-Mutated Advanced Breast Cancer Post-Endocrine and CDK4/6 Inhibitors
Data & Insights
Has run more than one trial at 53 of 189 partner sites.
Specializations
Breast Cancer Specialization
This investigator focuses on advanced therapeutic approaches for hormone receptor-positive (HR+) and HER2-negative breast cancer, particularly in cases of metastatic progression.
- Metastatic Breast Cancer Treatment
- Hormone Receptor-Positive Disease Management
- Post-Endocrine Therapy Interventions
Expertise includes evaluation of novel therapeutic agents for patients who have progressed following endocrine-based regimens.
Precision Medicine Applications
The investigator specializes in targeted therapies for patients with ESR1-mutated breast cancer, focusing on combination treatment strategies.
- ESR1 Mutation Analysis
- Targeted Therapeutic Approaches
- Combination Treatment Protocols
Particular attention is given to developing treatment options for patients who have progressed on CDK4/6 inhibitor therapy.
Advanced Treatment Evaluation
Expertise in assessing novel therapeutic compounds for advanced breast cancer, including comparative effectiveness studies.
- Treatment Response Assessment
- Progressive Disease Management
- Therapeutic Resistance Strategies
Focus on evaluating progression-free survival outcomes in advanced breast cancer populations.
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