Michaela T.
- Country
- Czechia
- Department
- Neurologická klinika 1.LF UK a VFN
Research Overview
- Phase 3 Randomized Double-Blind Trial of Riliprubart Versus Intravenous Immunoglobulin in Chronic Inflammatory Demyelinating Polyneuropathy
- Phase 3 Extension Study on Long-term Safety and Tolerability of Tolebrutinib in Relapsing and Progressive Multiple Sclerosis
- Long-term Evaluation of Riliprubart (SAR445088) Safety and Efficacy in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients
Data & Insights
Has run more than one trial at 83 of 228 partner sites.
Specializations
Neurology and Neuroimmunology
Clinical activity is centered on multiple sclerosis, including relapsing and progressive forms, as well as related central nervous system disorders such as myelin oligodendrocyte glycoprotein antibody-associated disease, multifocal motor neuropathy, and Parkinson disease.
- Multiple sclerosis
- Myelin oligodendrocyte glycoprotein antibody-associated disease
- Multifocal motor neuropathy
- Parkinson disease
The portfolio also includes spasticity, cervical dystonia, narcolepsy, and idiopathic hypersomnia, reflecting a strong therapeutic interest in chronic neurological and sleep-related conditions.
Cardiovascular and Thrombotic Disease
Research involvement spans acute myocardial infarction, heart failure, atrial fibrillation, cardiogenic shock, and broader atherosclerotic cardiovascular disease, with attention to both acute and long-term cardiometabolic risk.
- Acute myocardial infarction
- Heart failure
- Atrial fibrillation
- Cardiogenic shock
Additional interests include pulmonary hypertension, hypertrophic cardiomyopathy, transthyretin amyloid cardiomyopathy, and venous thromboembolism, highlighting engagement with vascular and structural heart disease.
Renal and Autoimmune Disorders
The investigator is active in IgA nephropathy, focal segmental glomerulosclerosis, chronic kidney disease, and rapidly progressive glomerulonephritis, alongside other immune-mediated renal conditions.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Chronic kidney disease
- Rapidly progressive glomerulonephritis
Work also extends to anti-GBM antibody disease, ANCA-associated vasculitis, systemic lupus erythematosus, and immune thrombocytopenia, indicating a strong focus on autoimmune and inflammatory disease management.
Hematologic Malignancies and Myeloid Disorders
Clinical research includes multiple myeloma, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, covering both indolent and aggressive blood cancers.
- Multiple myeloma
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Follicular lymphoma
The portfolio further includes myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia, reflecting involvement in therapies for marrow failure syndromes and leukemic transformation.
Ophthalmology, Metabolic, and Inflammatory Conditions
Research participation also covers diabetic macular edema, wet age-related macular degeneration, uveitic macular edema, and thyroid eye disease, indicating activity in retinal and orbital inflammatory disease.
- Diabetic macular edema
- Age-related macular degeneration
- Thyroid eye disease
- Uveitic macular edema
Further areas include obesity, severe hypertriglyceridemia, non-alcoholic steatohepatitis, atopic dermatitis, and ulcerative colitis, showing engagement with metabolic, dermatologic, and gastrointestinal therapeutics.
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