Michael L.
- Country
- Germany
- Department
- Pediatric and Adolescent medicine Department
Research Overview
- A randomised, double-blind, placebo-controlled, parallel group trial evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of BI 1291583 one tablet once daily over 12 weeks versus placebo in adult patients with cystic fibrosis bronchiectasis (ClairaflyTM)
- Evaluation of Long-term Safety and Efficacy of Tezacaftor, Deutivacaftor, and Vanzacaftor Combination Therapy in Patients with Cystic Fibrosis
- Efficacy and Safety Evaluation of PQ Grass 27600 SU in Pediatric Patients with Grass Pollen-Induced Seasonal Allergic Rhinitis/Rhinoconjunctivitis
Data & Insights
Has run more than one trial at 71 of 226 partner sites.
Specializations
Paediatric Oncology and Haematologic Malignancies
Clinical research activity includes childhood and adolescent cancers with a strong focus on acute lymphoblastic leukaemia, acute myeloid leukaemia, myelodysplastic syndromes, lymphoma, and neuroblastoma, alongside other rare paediatric solid tumours.
- Acute lymphoblastic leukaemia
- Acute myeloid leukaemia
- Myelodysplastic syndromes
- Diffuse large B-cell lymphoma
- Neuroblastoma
The investigator is also involved in stem cell transplantation and graft-versus-host disease settings linked to blood cancers and post-transplant care.
Thoracic, Urological, and Gastrointestinal Cancer
Another major area of interest is solid tumours, particularly non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, prostate cancer, and gastroesophageal and colorectal cancers.
- Non-small cell lung cancer
- Renal cell carcinoma
- Urothelial carcinoma
- Prostate cancer
- Gastroesophageal cancer
Research also extends to head and neck squamous cell carcinoma, bladder cancer, and advanced metastatic disease across multiple tumour types.
Immunology, Autoimmune Disease, and Inflammatory Bowel Disease
The clinical portfolio includes immune-mediated disorders such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, myasthenia gravis, and idiopathic inflammatory myopathies, with additional work in Crohn’s disease and ulcerative colitis.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Crohn’s disease
- Ulcerative colitis
- Generalized myasthenia gravis
Interest also covers immune thrombocytopenia, autoimmune encephalitis, and other refractory inflammatory conditions.
Cardiorenal, Critical Care, and Transplant Medicine
Research activity spans heart failure, atherosclerotic cardiovascular disease, atrial fibrillation, acute myocardial infarction, chronic kidney disease, and acute kidney injury, including complications in high-risk hospital and intensive care settings.
- Heart failure
- Chronic kidney disease
- Acute kidney injury
- Atrial fibrillation
- Acute-on-chronic liver failure
Additional involvement includes liver transplantation, kidney transplantation, sepsis, and respiratory failure in acutely ill patients.
Neurology, Respiratory Disease, and Rare Genetic Disorders
The investigator is also active in neurological and rare-disease research, including multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, migraine, and Alzheimer’s disease, together with chronic respiratory disorders such as asthma, bronchiectasis, and cystic fibrosis.
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Epilepsy
- Asthma
- Cystic fibrosis
Other areas include migraine, sensorineural hearing loss, and selected genetic and metabolic disorders affecting children and adults.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.