Michael C. S.
- Country
- Spain
- Department
- Hematology
Research Overview
- B7841007 - An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Marstacimab Prophylaxis in Severe (Coagulation Factor Activity <1%) Hemophilia A Participants With or Without Inhibitors or Moderately Severe to Severe Hemophilia B Participants (Coagulation Factor Activity ≤2%) With or Without Inhibitors
- A Multicenter, Randomized, Open-Label Study Comparing Romiplostim Plus Dexamethasone Versus Dexamethasone in Newly Diagnosed Primary Immune Thrombocytopenia
- Evaluation of Emicizumab Prophylaxis on Joint Health and Physical Activity in Patients Aged ≥13 to <70 with Severe or Moderate Hemophilia A Without FVIII Inhibitors
Data & Insights
Has run more than one trial at 18 of 96 partner sites.
Specializations
Hematologic Malignancies and Related Cancers
Clinical activity includes studies in acute myeloid leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, Hodgkin lymphoma, and multiple myeloma, with additional interest in chronic lymphocytic leukemia and other relapsed or refractory blood cancers.
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Hodgkin lymphoma
Therapeutic focus also extends to immune thrombocytopenia, hemophilia, and paroxysmal nocturnal hemoglobinuria, reflecting involvement across malignant and non-malignant hematology.
Thoracic Oncology
Research involvement is prominent in non-small cell lung cancer, small cell lung cancer, and unresectable or metastatic lung cancer, including biomarker-defined disease such as EGFR-mutated, ALK-positive, ROS1-positive, and KRAS G12C-mutant tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- EGFR-mutated lung cancer
- ALK-positive lung cancer
Additional interest includes metastatic lung cancer, resectable non-small cell lung cancer, and lung cancer with brain metastasis, spanning early, advanced, and recurrent settings.
Breast, Gynecologic, and Genitourinary Oncology
Investigational work covers breast cancer across hormone receptor-positive, HER2-positive, HER2-low, and triple-negative breast cancer, with attention to both early-stage and metastatic disease.
- Breast cancer
- Triple-negative breast cancer
- Ovarian cancer
- Endometrial cancer
Activity also includes cervical cancer, urothelial cancer, upper tract urothelial carcinoma, and prostate cancer, alongside selected solid tumors with actionable molecular alterations.
Cardiovascular and Thrombotic Disease
Clinical interests include heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, myocardial infarction, stroke, and pulmonary embolism, with studies also addressing high-risk vascular prevention.
- Heart failure
- Atrial fibrillation
- Stroke
- Atherosclerotic cardiovascular disease
Further focus is seen in transthyretin amyloid cardiomyopathy, hypertrophic cardiomyopathy, and thromboembolic disease, supporting therapeutic interest across structural, ischemic, and embolic cardiovascular conditions.
Autoimmune, Metabolic, and Organ-Specific Disorders
Research involvement extends to rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, and polymyalgia rheumatica, with additional activity in multiple sclerosis and dermatomyositis.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Psoriatic arthritis
- Multiple sclerosis
Metabolic and organ-specific areas include type 2 diabetes, obesity, non-alcoholic steatohepatitis, chronic kidney disease, and kidney transplant rejection, together with selected respiratory and infectious disorders such as bronchiectasis and COVID-19.
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