Mauro V.
- Country
- Italy
- Department
- Gastroenterologia
Research Overview
- N1T-MC-MALO: A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes (SYNERGY-Outcomes); N1T-MC-TZ01 Tirzepatide in participants with high-risk MASLD; N1T-MC-RT01 Retatrutide in participants with high-risk MASLD
- Efficacy and Safety Evaluation of Volixibat in Treating Cholestatic Pruritus in Primary Biliary Cholangitis: A Randomized, Double-Blind, Placebo-Controlled Trial
- Evaluation of Tobevibart and Elebsiran Efficacy and Safety in Chronic Hepatitis D Virus Infection Unresponsive to Bulevirtide Therapy
Data & Insights
Has run more than one trial at 26 of 146 partner sites.
Specializations
Hepatology and liver disease
The clinical research profile includes chronic hepatitis B, hepatitis D virus infection, metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, alcohol-related liver disease, and hepatocellular carcinoma, with interest in conditions affecting liver function, cholestasis, and advanced hepatic complications.
- Chronic hepatitis B
- Hepatitis D infection
- MASH and MASLD
- Hepatocellular carcinoma
- Cholestatic pruritus
Research activity also extends to biliary atresia, primary biliary cholangitis, progressive familial intrahepatic cholestasis, and other liver-centered therapeutic areas.
Gastroenterology and inflammatory bowel disease
There is clear involvement in Crohn's disease, ulcerative colitis, and broader inflammatory bowel disease, reflecting a therapeutic focus on chronic intestinal inflammation and symptom control in gastrointestinal disorders.
- Crohn's disease
- Ulcerative colitis
- Inflammatory bowel disease
- Colonic disease
- Gastroesophageal and gastric cancer
The portfolio also includes colorectal cancer, gastric adenocarcinoma, and pancreatic ductal adenocarcinoma, linking digestive disease management with gastrointestinal oncology.
Cardiovascular and thrombotic disease
Clinical interests span heart failure, atrial fibrillation, acute coronary syndrome, myocardial infarction, stroke prevention, and venous thromboembolism, with a strong emphasis on cardiovascular risk reduction and vascular protection.
- Heart failure
- Atrial fibrillation
- Acute myocardial infarction
- Stroke prevention
- Venous thromboembolism
Additional work includes atherosclerotic cardiovascular disease, pulmonary hypertension, cardiac amyloidosis, and calcific aortic valve stenosis.
Hematology, lymphoma, and cell therapy
The investigator is active across acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, and multiple B-cell and T-cell lymphoma subtypes, indicating a broad commitment to blood cancers and advanced hematologic treatment strategies.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Cell and gene therapy
Research also covers CAR T-cell therapy, gene-modified T cells, follicular lymphoma, mantle cell lymphoma, and peripheral T-cell lymphoma.
Solid tumors and metabolic disease
Therapeutic interests include breast cancer, non-small cell lung cancer, melanoma, prostate cancer, renal cell carcinoma, and bladder cancer, alongside studies in obesity and type 2 diabetes.
- Breast cancer
- Non-small cell lung cancer
- Melanoma
- Prostate cancer
- Obesity and type 2 diabetes
Additional involvement includes metastatic solid tumors, HER2-positive disease, hormone receptor-positive breast cancer, and metabolic kidney disease.
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