Matteo L.
- Country
- Italy
- Department
- Oncologia Medica e Terapia Biomolecolare Universitaria
Research Overview
- Sotorasib and Combination Therapy Versus Standard Chemotherapy in Treatment-Naïve Patients with KRAS p.G12C-Mutated Metastatic Colorectal Cancer
- Phase 3 Randomized Study of Tucatinib, Trastuzumab, and mFOLFOX6 vs. mFOLFOX6 with Cetuximab or Bevacizumab in HER2+ Metastatic Colorectal Cancer
- Phase 3 Randomized Study of Intermittent vs. Continuous Panitumumab Plus FOLFIRI in Unresectable Left-Sided RAS/B-RAF Wild-Type Metastatic Colorectal Cancer
Data & Insights
Has run more than one trial at 127 of 331 partner sites.
Specializations
Prostate Cancer Research
The investigator specializes in treating advanced forms of prostate cancer, with particular focus on metastatic castration-resistant prostate cancer and biochemically recurrent prostate cancer.
- Hormone Therapy Resistance
- PSA-Based Disease Monitoring
- Novel Therapeutic Combinations
Current research involves evaluating targeted therapies in combination with androgen deprivation therapy for various stages of prostate cancer progression.
Colorectal Cancer Innovation
The investigator conducts research in metastatic colorectal cancer treatment, with expertise in both HER2-positive and RAS-mutated disease variants.
- Targeted Molecular Therapies
- Combination Treatment Strategies
- Biomarker-Driven Approaches
Areas of focus include investigating novel therapeutic combinations and treatment scheduling in unresectable colorectal cancer.
Precision Medicine Applications
The investigator applies precision medicine principles in developing treatment strategies for advanced cancers, particularly focusing on molecular profiling and targeted interventions.
- Treatment Resistance Mechanisms
- Biomarker Development
- Therapeutic Sequencing
Research emphasis includes optimization of treatment protocols based on specific genetic markers and disease characteristics.
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