Mathilde S.
- Country
- Denmark
- Department
- Clinical Translational Research
Research Overview
Data & Insights
Has run more than one trial at 0 of 2 partner sites.
Specializations
Diabetes Therapeutics
Focus on innovative strategies to improve glycaemic control and disease progression in Type 1 Diabetes and Type 2 Diabetes, including monogenic forms such as HNF1A‑MODY and HNF4A‑MODY.
- Targeted glucose‑lowering agents for MODY
- Adjunctive treatments to preserve β‑cell function
- Optimization of automated insulin delivery systems
Research conducted at the Steno Diabetes Center Copenhagen.
Renal Protection and CKD Management
Investigation of therapies aimed at slowing progression of Chronic Kidney Disease and reducing albuminuria in patients with diabetic kidney involvement.
- Combination mineralocorticoid receptor antagonists with SGLT2 inhibitors
- Biomarker‑guided treatment strategies for renal outcomes
- Renal oxygenation imaging as a therapeutic endpoint
Emphasis on early intervention to preserve renal function.
Cardiovascular Risk Management
Evaluation of interventions that address Atherosclerotic Cardiovascular Disease, hypertension, and heart failure risk in diabetic populations.
- Anti‑inflammatory agents to reduce residual cardiovascular risk
- Imaging‑based strategies for subclinical coronary disease
- Finerenone‑based regimens for cardiovascular event reduction
Studies target high‑risk cohorts across Europe.
Obesity and Metabolic Health
Research on therapeutic approaches for obesity, overweight, and metabolic dysregulation, including post‑menopausal women with high body‑mass index.
- Dual agonists for body‑weight reduction
- Metabolic effects of adipose tissue modulation
- Integration of lifestyle and pharmacologic interventions
Focus on improving cardiovascular and renal outcomes through weight management.
Neuropathy and Pain Management
Targeted studies on painful complications of diabetes, including Diabetic Peripheral Neuropathy, autonomic neuropathy, and acute Charcot Foot.
- CGRP monoclonal antibodies for neuropathic pain relief
- Platelet aggregation profiling in diabetic vascular disease
- Bone metabolism modulation in Charcot neuroarthropathy
Therapeutic focus on reducing pain severity and improving functional outcomes.
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