Mathias R.
- Country
- France
- Department
- Pediatric Gastroenterology, Hepatology and Nutrition
Research Overview
- Efficacy and Safety Evaluation of Odevixibat in Pediatric Biliary Atresia Post-Kasai Hepatoportoenterostomy: A Double-Blind, Randomized, Placebo-Controlled Trial
- An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat (A4250) in Children with Biliary Atresia (BOLD-EXT)
- Phase 3 Randomized Double-Blind Placebo-Controlled Study on Maralixibat Chloride Efficacy and Safety in Cholestatic Pruritus Treatment
Data & Insights
Has run more than one trial at 20 of 33 partner sites.
Specializations
Pediatric Hepatology
The investigator specializes in treating rare pediatric liver conditions, with particular focus on biliary atresia and post-surgical management of children who have undergone Kasai hepatoportoenterostomy.
- Native liver survival optimization
- Post-surgical therapeutic interventions
- Pediatric liver disease management
The research extends to evaluating innovative therapeutic approaches for improving long-term outcomes in pediatric liver conditions.
Rare Genetic Disorders
The investigator focuses on treating Alagille syndrome, examining therapeutic interventions and their long-term effectiveness in managing this genetic disorder.
- Genetic liver disease therapy
- Long-term safety monitoring
- Treatment tolerability assessment
Expertise includes evaluating novel treatments for rare genetic conditions affecting liver function.
Cholestatic Conditions
The investigator specializes in treating cholestatic pruritus and related complications in liver disorders, focusing on innovative therapeutic approaches.
- Pruritus management
- Symptom severity reduction
- Quality of life improvement
Research interests include developing effective treatments for cholestatic conditions and associated symptoms.
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