Massimo A.
- Country
- Italy
- Department
- Scienze dell'emergenza, anestesiologiche e della rianimazione
Research Overview
- A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
- Phase 2b Multicenter, Randomized, Double-Blind, Placebo-Controlled Study on TIN816 Efficacy and Safety in Sepsis-Associated Acute Kidney Injury
- Evaluation of Conservative Versus Conventional Oxygen Administration on ICU Mortality in Mechanically Ventilated Critically Ill Adults Using Nitrous Oxide and Oxygen
Data & Insights
Has run more than one trial at 26 of 141 partner sites.
Specializations
Critical Care and Respiratory Medicine
Clinical trial activity includes acute respiratory distress syndrome, mechanical ventilation, sepsis, pneumonia, and severe inflammatory lung disease, with interest in chronic obstructive pulmonary disease, asthma, and interstitial lung disease.
- Acute respiratory failure
- Sepsis-associated organ dysfunction
- Severe asthma
- Interstitial lung disease
The research landscape also includes pulmonary fibrosis, respiratory syncytial virus prevention, and infection-related pulmonary complications.
Oncology and Hematologic Malignancies
Research involvement spans breast cancer, lung cancer, ovarian cancer, colorectal cancer, prostate cancer, and gastrointestinal cancers, alongside lymphoma, leukemia, and multiple myeloma.
- Solid tumors
- Hematologic malignancies
- Gynecologic cancers
- Head and neck cancer
Therapeutic interests also extend to targeted therapy, immunotherapy, and treatment strategies for advanced or metastatic disease.
Autoimmune, Inflammatory, and Rare Diseases
Clinical research includes systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, Sjögren’s syndrome, systemic sclerosis, and myasthenia gravis, with additional focus on bullous pemphigoid, vitiligo, and hidradenitis suppurativa.
- Autoimmune connective tissue disease
- Neuromuscular disorders
- Inflammatory skin disease
- Immune-mediated thrombocytopenia
The portfolio also covers myositis, vasculitis, and other immune-mediated conditions requiring specialized therapeutic approaches.
Cardiometabolic and Hepatology
Trial activity reflects interest in myocardial infarction, atherosclerotic cardiovascular disease, heart failure, atrial fibrillation, thromboembolic disease, and congenital antithrombin deficiency.
- Cardiovascular risk reduction
- Thrombosis and coagulation disorders
- Metabolic dysfunction-associated steatohepatitis
- Cholestatic and chronic liver disease
Additional involvement includes type 2 diabetes, obesity, non-alcoholic steatohepatitis, primary biliary cholangitis, and alcohol-related liver disease.
Neurology, Nephrology, and Ophthalmology
Research interests include Alzheimer’s disease, Parkinson’s disease, epilepsy, multiple sclerosis, myotonic dystrophy, and spinal muscular atrophy, together with progressive supranuclear palsy and refractory status epilepticus.
- Neurodegenerative disease
- Autoimmune neurologic disease
- Chronic kidney disease
- Retinal disease
Therapeutic activity also covers IgA nephropathy, focal segmental glomerulosclerosis, diabetic macular edema, and age-related macular degeneration.
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