Marlène M. E.
- Country
- France
- Department
- Pneumology
Research Overview
- A Phase IIb Randomized Study to Evaluate the Efficacy and Safety of AZD0292 in Patients with Bronchiectasis and Chronic Pseudomonas aeruginosa Colonization
- Non‑inferiority of Azithromycin Withdrawal vs Continuation in Stable Non‑Cystic Fibrosis Bronchiectasis after ≥1 Year of Therapy: Multicenter Randomized Controlled Trial
- Evaluation of Amikacin Liposome Inhalation Suspension in Combination Therapy for Mycobacterium xenopi Pulmonary Infection: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 106 of 293 partner sites.
Specializations
Thoracic oncology
Clinical research activity includes non-small cell lung cancer, small cell lung cancer, and other advanced thoracic malignancies, with interest in biomarker-defined disease and treatment-resistant settings.
- Advanced NSCLC
- SCLC
- Mesothelioma
- Actionable molecular alterations
Work also extends to resectable and metastatic lung cancer, including disease characterized by EGFR, ALK, ROS1, KRAS G12C, and MET alterations.
Breast and gynecologic cancers
The investigator is involved in trials for breast cancer across hormone receptor-positive, HER2-negative, triple-negative, and HER2-expressing disease, as well as advanced gynecologic malignancies.
- Hormone receptor-positive breast cancer
- Triple-negative breast cancer
- Ovarian cancer
- Endometrial cancer
Research interest also includes cervical cancer, vulvar cancer, and other solid tumors with recurrent or metastatic disease.
Hematologic malignancies
Clinical trial involvement covers a broad spectrum of blood cancers, with emphasis on relapsed, refractory, and high-risk hematologic disease.
- Acute myeloid leukemia
- Multiple myeloma
- Lymphoma
- Myelodysplastic syndromes
Additional activity includes chronic lymphocytic leukemia, acute lymphoblastic leukemia, and Waldenström macroglobulinemia.
Autoimmune and inflammatory diseases
The investigator also participates in studies of immune-mediated disorders affecting the skin, joints, lungs, kidneys, and connective tissue.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Inflammatory bowel disease
- Hidradenitis suppurativa
Related interests include vasculitis, psoriatic arthritis, atopic dermatitis, and interstitial lung disease linked to autoimmune conditions.
Cardiopulmonary and rare disease medicine
Research activity spans pulmonary arterial hypertension, heart failure, atrial fibrillation, and selected rare disorders involving the liver, kidney, and amyloid pathways.
- Pulmonary arterial hypertension
- Heart failure
- Transthyretin amyloidosis
- Chronic liver disease
Additional involvement includes pulmonary fibrosis, kidney disease, and amyloidosis with cardiac or systemic involvement.
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