Mark A.
- Country
- Denmark
- Department
- Medical Gastrointestinal Diseases
Research Overview
- Phase 2 Study of LY4268989 Co-administered with Mirikizumab in Adults with Moderately to Severely Active Ulcerative Colitis
- Phase 3 Randomized Double-Blind Placebo-Controlled Study of Tulisokibart Efficacy and Safety in Moderately to Severely Active Crohn's Disease
- Model-Informed Precision Dosing of Vedolizumab and Ustekinumab in Maintaining Remission of Inflammatory Bowel Disease: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 143 of 178 partner sites.
Specializations
Cardiovascular medicine
Clinical research activity includes acute myocardial infarction, coronary artery bypass grafting, atrial fibrillation, cardiac arrest, heart failure, and atherosclerotic cardiovascular disease, with interest in risk reduction, post-procedural outcomes, and prevention of recurrent events.
- Acute coronary syndromes
- Heart failure with reduced ejection fraction
- Stroke prevention
- Lipid disorders
Work in this area also extends to cardiometabolic disease, including obesity-related cardiovascular risk and therapies aimed at improving long-term vascular outcomes.
Inflammatory and autoimmune disease
Research involvement spans Crohn’s disease, ulcerative colitis, primary sclerosing cholangitis, psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus, reflecting a strong therapeutic focus on immune-mediated disorders.
- Inflammatory bowel disease
- Autoimmune neuropathies
- Vasculitis
- Chronic urticaria
Additional activity includes myasthenia gravis, Sjögren’s syndrome, and immune thrombocytopenia, with attention to therapies that modify inflammatory activity and disease burden.
Respiratory and interstitial lung disease
Clinical trial involvement covers asthma, chronic obstructive pulmonary disease, bronchiectasis, pulmonary sarcoidosis, and idiopathic pulmonary fibrosis, with emphasis on chronic airway inflammation and progressive fibrotic lung disease.
- Severe asthma
- Progressive pulmonary fibrosis
- Bronchiectasis with chronic infection
- Interstitial lung disease
Research interest also includes severe viral lung infections and nontuberculous mycobacterial lung infection, supporting therapeutic development in complex pulmonary disease.
Oncology and hematologic malignancies
Research activity spans breast cancer, colorectal cancer, lung cancer, bladder cancer, endometrial cancer, and ovarian cancer, together with multiple hematologic cancers such as multiple myeloma, lymphoma, and acute leukemia.
- Gastrointestinal and genitourinary cancers
- Myeloproliferative and plasma cell disorders
- Pediatric brain tumors
- Metastatic solid tumors
Additional involvement includes glioblastoma, medulloblastoma, diffuse glioma, and melanoma, indicating broad engagement across both solid and blood cancers.
Metabolic, renal, and amyloid disorders
Investigational work includes type 2 diabetes, dyslipidemia, chronic kidney disease, IgA nephropathy, liver disease, and amyloidosis, with a therapeutic emphasis on systemic complications and organ protection.
- Transthyretin amyloid cardiomyopathy
- Al amyloidosis
- Proteinuric kidney disease
- Alcohol-related liver disease
Research also covers osteoporosis and hypertriglyceridemia, highlighting interest in chronic disease management across metabolic and end-organ domains.
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