Marion Q.
- Country
- France
- Department
- neurolgy, epilepsy unit
Research Overview
- Phase 2a Open‑Label Study of Adjunctive PTI5803 (Probenecid) in Adolescents and Adults (≥14 y) With Drug‑Resistant Seizures Due to Focal Cortical Dysplasia
- Long‑Term Safety and Tolerability of Probenecid (PTI5803) as Adjunctive Therapy in Patients ≥ 14 Years with Drug‑Resistant Focal Epilepsy due to Focal Cortical Dysplasia
Data & Insights
Has run more than one trial at 3 of 5 partner sites.
Specializations
Epilepsy & Seizure Disorders
The investigator leads studies on focal epilepsy and generalized seizure syndromes, emphasizing novel therapeutic pathways for drug‑resistant cases.
- Focal onset seizures
- Primary generalized tonic‑clonic seizures
- Drug‑resistant epilepsy associated with cortical dysplasia
Collaboration with the epilepsy unit at Fondation A De Rothschild supports multidisciplinary patient care.
Cerebrovascular & Stroke
Focused on acute and secondary prevention of ischemic stroke, including large‑core and basilar artery occlusion subtypes.
- Acute ischemic stroke with large core
- Basilar artery occlusion
- High‑risk transient ischemic attack
Research integrates advanced imaging biomarkers to refine therapeutic windows.
Neurodegenerative & Demyelinating Diseases
Active investigations into disease‑modifying strategies for multiple sclerosis and cognitive decline in Alzheimer’s disease.
- Relapsing‑remitting multiple sclerosis
- Primary progressive multiple sclerosis
- Alzheimer’s disease cognitive support
Efforts aim to balance efficacy with long‑term safety in chronic neuro‑inflammation.
Ocular & Vision Disorders
Extensive work on retinal and corneal pathologies, ranging from age‑related macular degeneration to Fuchs endothelial corneal dystrophy.
- Neovascular age‑related macular degeneration
- Geographic atrophy
- Persistent corneal epithelial defects
Projects leverage intravitreal delivery platforms and novel topical agents.
Autoimmune Neuromuscular & Peripheral Nerve Disorders
Research addresses immune‑mediated conditions such as myasthenia gravis and chronic inflammatory demyelinating polyneuropathy.
- Generalized myasthenia gravis
- Ocular myasthenia gravis
- Chronic inflammatory demyelinating polyneuropathy
Therapeutic exploration includes targeted biologics and immunomodulatory regimens.
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