Mariëlle K.
- Country
- The Netherlands
- Department
- Internal medicine / Oncology
Research Overview
- Evaluation of Image-Guided De-Escalation of Neoadjuvant Chemotherapy with Trastuzumab, Pertuzumab, and Drug Combination in HER2-Positive Breast Cancer
- Evaluation of CDK4/6 Inhibitors Abemaciclib, Palbociclib, and Ribociclib in HR+/HER2- Metastatic Breast Cancer: A Randomized Clinical Trial
- Phase 2 Randomized Study of Liposomal Irinotecan, Carboplatin, and Oxaliplatin in First-Line Treatment of Metastatic or Locally Advanced Esophagogastric Cancer
Data & Insights
Has run more than one trial at 53 of 69 partner sites.
Specializations
Gastrointestinal Oncology
This investigator specializes in developing treatments for advanced esophagogastric cancer, with particular focus on innovative therapeutic approaches for patients with metastatic and locally advanced conditions.
- Esophageal Cancer Treatment
- Gastric Cancer Management
- Advanced Cancer Therapeutics
The research encompasses evaluation of liposomal-based treatments and various platinum-based therapeutic combinations in gastrointestinal oncology.
Treatment Innovation
The investigator's work centers on comparing different therapeutic approaches in first-line treatment modalities for gastrointestinal cancers, with particular attention to treatment efficacy and neurological side effects.
- Novel Drug Combinations
- Treatment Optimization
- Side Effect Management
Key areas of focus include the assessment of disease progression patterns and therapeutic response in advanced cancer cases.
Clinical Outcomes
The investigator evaluates progression-free survival in patients with advanced gastrointestinal cancers, focusing on the comparative effectiveness of different treatment regimens.
- Survival Analysis
- Treatment Response Assessment
- Quality of Life Evaluation
Research priorities include monitoring neurotoxicity impacts and overall treatment outcomes in cancer therapy.
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