Marieke D. B.
- Country
- Belgium
- Department
- Department of Pediatrics
Research Overview
- Efficacy and Safety of Teplizumab Versus Placebo in Stage 3 Type 1 Diabetes Patients Aged 1-25: A Randomized, Double-Blind, Phase 3 Trial
- A Phase 2/3 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Atumelnant Treatment in Pediatric Participants with Congenital Adrenal Hyperplasia Including a Long-Term Extension
Data & Insights
Has run more than one trial at 8 of 90 partner sites.
Specializations
Paediatric haematology and oncology
Clinical research in Department of Pediatrics at the University of Antwerpacute lymphoblastic leukaemia, lymphoma, neuroblastoma, medulloblastoma, and sarcomas.
- Acute lymphoblastic leukaemia
- Hodgkin lymphoma
- Neuroblastoma
- Medulloblastoma
Interest also extends to relapsed and refractory haematologic malignancies and genetically modified T-cell approaches in paediatric care.
Breast cancer and solid tumours
The investigator is involved in studies across breast cancer and a broad range of solid tumours, including non-small cell lung cancer, colorectal cancer, gastric cancer, pancreatic cancer, and ovarian cancer.
- Hormone receptor-positive breast cancer
- HER2-positive breast cancer
- Non-small cell lung cancer
- Colorectal cancer
Therapeutic interest includes targeted therapy, endocrine treatment, and treatment options for advanced and metastatic disease.
Hepatology and metabolic liver disease
Research activity covers cirrhosis, portal hypertension, hepatic encephalopathy, primary biliary cholangitis, primary sclerosing cholangitis, and metabolic dysfunction-associated steatotic liver disease.
- Chronic liver disease
- Non-alcoholic steatohepatitis
- Hepatocellular carcinoma
- Alpha-1 antitrypsin deficiency-associated liver disease
Additional focus includes cholestatic pruritus, hepatic decompensation, and fibroinflammatory liver disorders.
Respiratory, cardiovascular, and immune-mediated disorders
Clinical interests also span asthma, chronic obstructive pulmonary disease, atrial fibrillation, atherosclerotic cardiovascular disease, and heart failure, alongside immune-mediated conditions such as inflammatory bowel disease and rheumatoid arthritis.
- Severe asthma
- Chronic obstructive pulmonary disease
- Atrial fibrillation
- Inflammatory bowel disease
Research involvement further includes migraine, multiple sclerosis, and epilepsy within broader therapeutic development.
Rare diseases and paediatric metabolic conditions
The investigator participates in studies of rare genetic and metabolic diseases, including spinal muscular atrophy, tuberous sclerosis complex, myotonic dystrophy, Fabry disease, and autosomal dominant polycystic kidney disease.
- Spinal muscular atrophy
- Tuberous sclerosis complex-related epilepsy
- Fabry disease
- Autosomal dominant polycystic kidney disease
Interest also includes paediatric obesity, type 2 diabetes, and growth disorders in children.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.