Marica G.
- Country
- Italy
- Department
- Oncologia Medica
Research Overview
- Phase 3 Study Comparing Rinatabart Sesutecan Versus Investigator's Choice in Patients With Recurrent or Progressive Endometrial Cancer Following Platinum-Based and PD(L)-1 Therapy
- Phase 3 Study of Vepugratinib and Combination Therapy in Adults with Untreated FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma
- A Phase III, Randomized, Open-Label, Multicenter, Global Study of Puxitatug Samrotecan (AZD8205) Monotherapy versus Physician’s Choice of Chemotherapy in Participants with B7-H4-Selected Advanced/Metastatic Endometrial Cancer Who Progressed On or After Platinum-Based Chemotherapy and Anti-PD-1/Anti-PD-L1 Therapy (Bluestar-Endometrial01)
Data & Insights
Has run more than one trial at 85 of 239 partner sites.
Specializations
Thoracic Oncology
Clinical activity is centered on non-small cell lung cancer and small cell lung cancer, with interest across locally advanced, metastatic, resectable, and postoperative settings. The portfolio also includes biomarker-defined disease such as EGFR-mutated, ALK-rearranged, ROS1-positive, KRAS G12C-mutant, and c-Met-overexpressing tumors, as well as pleural mesothelioma.
- Non-small cell lung cancer
- Small cell lung cancer
- ALK- and EGFR-driven lung cancer
- KRAS G12C-mutant disease
- Pleural mesothelioma
Therapeutic interest extends to immunotherapy, targeted therapy, and combined systemic strategies in advanced lung malignancies.
Melanoma and Skin Cancer
Research involvement includes advanced melanoma, resected high-risk melanoma, and cutaneous squamous cell carcinoma, with attention to both unresectable and metastatic disease. The scope also covers mucosal melanoma and other high-risk skin tumors.
- Advanced melanoma
- Metastatic ocular/uveal melanoma
- Cutaneous squamous cell carcinoma
- Mucosal melanoma
- High-risk resected melanoma
The therapeutic focus includes checkpoint inhibition and adjuvant treatment approaches for relapse prevention and disease control.
Genitourinary Oncology
Clinical interests include urothelial carcinoma, muscle-invasive bladder cancer, non-muscle invasive bladder cancer, and broader urinary tract carcinoma. The portfolio also extends to endometrial cancer, ovarian cancer, fallopian tube cancer, and vulvar cancer.
- Bladder cancer
- Urothelial carcinoma
- Endometrial cancer
- Ovarian cancer
- Vulvar cancer
Therapeutic activity emphasizes immune-based combinations, antibody-drug conjugates, and perioperative strategies in gynecologic and urothelial malignancies.
Hematologic Malignancies
Research spans acute myeloid leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and marginal zone lymphoma. Additional interest includes Hodgkin lymphoma, Waldenström’s macroglobulinemia, and myelodysplastic syndromes.
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Myelodysplastic syndromes
The therapeutic landscape includes BTK inhibition, B-cell-directed therapy, and treatment approaches for myeloproliferative neoplasms.
Breast, Gastrointestinal, and Other Solid Tumors
Additional trial involvement covers breast cancer, including HER2-positive, HER2-low, triple-negative, and hormone receptor-positive subtypes, as well as gastric cancer, gastroesophageal cancer, colorectal cancer, rectal cancer, and small bowel adenocarcinoma. The portfolio also includes pancreatic ductal adenocarcinoma and head and neck squamous cell carcinoma.
- Breast cancer
- Colorectal cancer
- Gastric and gastroesophageal cancer
- Head and neck squamous cell carcinoma
- Pancreatic ductal adenocarcinoma
Therapeutic interest is directed toward antibody-drug conjugates, immunotherapy, and molecularly guided treatment in advanced solid tumors.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.