Mariano P. P.
- Country
- Spain
- Department
- Servicio de Oncología Médica
Research Overview
Data & Insights
Has run more than one trial at 528 of 830 partner sites.
Specializations
Thoracic Oncology
Clinical research in non-small cell lung cancer and small cell lung cancer, with attention to advanced, metastatic, resectable, and biomarker-defined disease, including EGFR-mutated, ALK-positive, KRAS G12C-mutant, and RET-fusion-positive tumors.
- Advanced and metastatic lung cancer
- Resectable and perioperative non-small cell lung cancer
- Biomarker-driven thoracic malignancies
- Small cell lung cancer
Work in this area also includes treatment strategies for recurrent disease and lung cancer with brain metastasis, reflecting a strong focus on oncology innovation.
Breast, Gastrointestinal, and Hepatobiliary Cancer
Research activity spans breast cancer, colorectal cancer, endometrial cancer, gastric cancer, and hepatocellular carcinoma, with interest in both early-stage and advanced solid tumors.
- Hormone receptor-positive breast cancer
- HER2-positive and HER2-low breast cancer
- Metastatic colorectal cancer
- Hepatocellular carcinoma and biliary liver disease
The portfolio also extends to triple-negative breast cancer, gastroesophageal junction cancer, and solid tumor treatment development.
Hematologic Malignancies and Cellular Therapy-Related Disorders
Clinical interests include chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, multiple myeloma, and other B-cell malignancies.
- Chronic lymphocytic leukemia and small lymphocytic lymphoma
- Non-Hodgkin lymphoma subtypes
- Multiple myeloma and plasma cell disorders
- Transplant-associated hematologic complications
Research also covers graft-versus-host disease, thrombotic microangiopathy, and other complications linked to advanced hematology care.
Cardiovascular and Amyloid Disease
Investigational work includes heart failure, cardiomyopathy, atrial fibrillation, and atherosclerotic cardiovascular disease, alongside inherited and acquired amyloidosis.
- Transthyretin amyloid cardiomyopathy
- Hypertrophic and dilated cardiomyopathy
- Heart failure with preserved or reduced ejection fraction
- Stroke prevention in atrial fibrillation
Additional cardiovascular interests include pulmonary hypertension, valvular disease, and cardiorenal risk reduction.
Liver, Kidney, Inflammatory, and Respiratory Disease
Research spans chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, nonalcoholic steatohepatitis, cirrhosis, and inflammatory bowel disease, together with selected respiratory and immune-mediated disorders.
- Chronic kidney disease and glomerular disease
- Nonalcoholic steatohepatitis and cirrhosis-related complications
- Crohn’s disease and ulcerative colitis
- Asthma, COPD, and pulmonary fibrosis
The portfolio also includes autoimmune disease, atopic dermatitis, and infectious disease areas such as Clostridioides difficile infection and lung transplant-related infection prevention.
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