Marianna A.
- Country
- Italy
- Department
- Cardiology
Research Overview
- Efficacy and Safety Evaluation of Sotagliflozin in Patients with Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
- A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)
Data & Insights
Has run more than one trial at 4 of 86 partner sites.
Specializations
Cardiovascular Medicine
Research activity in cardiology centers on heart failure, atherosclerotic cardiovascular disease, atrial fibrillation, cardiogenic shock, hypertension, and thromboembolic risk, with interest in both prevention and treatment of advanced cardiac conditions.
- Heart failure
- Atherosclerotic cardiovascular disease
- Atrial fibrillation
- Hypertension
- Cardiac amyloidosis
The investigator is also involved in studies addressing ischemic stroke prevention, cardiac surgery-associated acute kidney injury, and recurrent pericarditis, reflecting a strong focus on cardiovascular complications and risk reduction.
Hematologic Malignancies
Clinical research includes a broad range of blood cancers, especially non-Hodgkin lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, and multiple myeloma.
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
- Follicular lymphoma
- Peripheral T-cell lymphoma
Additional interest extends to acute leukemias, myelodysplastic syndromes, myelofibrosis, and plasma cell disorders, supporting work in both relapsed disease and newly diagnosed settings.
Solid Tumors and Oncology
The oncology portfolio covers breast cancer, ovarian cancer, lung cancer, head and neck squamous cell carcinoma, endometrial cancer, renal cell carcinoma, and urothelial carcinoma, alongside other advanced solid tumors.
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
- Head and neck squamous cell carcinoma
- Endometrial cancer
Research also includes melanoma, prostate cancer, bladder cancer, and gastrointestinal malignancies, with attention to treatment strategies for recurrent, metastatic, and high-risk disease.
Autoimmune and Inflammatory Diseases
Therapeutic interests include systemic lupus erythematosus, lupus nephritis, systemic sclerosis, rheumatoid arthritis, psoriatic arthritis, and vasculitis, together with other immune-mediated disorders.
- Systemic lupus erythematosus
- Lupus nephritis
- Systemic sclerosis
- Rheumatoid arthritis
- Vasculitis
Work also spans atopic dermatitis, hidradenitis suppurativa, inflammatory myopathies, IgG4-related disease, and inflammatory bowel disease, indicating a wide therapeutic interest in chronic immune dysregulation.
Neurology, Nephrology, and Other Chronic Conditions
Further research involvement reaches Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, dementia, and schizophrenia, alongside renal and respiratory disorders such as chronic kidney disease, IgA nephropathy, and chronic obstructive pulmonary disease.
- Alzheimer’s disease
- Parkinson’s disease
- Multiple sclerosis
- Chronic kidney disease
- Chronic obstructive pulmonary disease
Additional domains include migraine, myasthenia gravis, interstitial lung disease, and transplant rejection, showing engagement with complex multisystem disease management.
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