Mariana Y. M.
- Country
- Bulgaria
- Department
- N/A
Research Overview
- Long-Term Extension Study of Imeroprubart in Adult Patients With Graves' Disease
- Phase 3 Randomized Double‑Masked Placebo‑Controlled Study of Subcutaneous Efgartigimod Alfa in Adults with Graves’ Disease Inadequately Controlled by Antithyroid Drugs
- Efficacy and Safety Evaluation of Efgartigimod PH20 SC in Adults with Thyroid Eye Disease: A Phase 3 Randomized, Double-Masked, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 79 of 173 partner sites.
Specializations
Autoimmune and connective tissue disease
Clinical research activity includes systemic lupus erythematosus, cutaneous lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis, with attention to both systemic and skin-dominant inflammatory disease.
- Systemic lupus erythematosus
- Cutaneous lupus erythematosus
- Sjögren’s syndrome
- Rheumatoid arthritis
- Psoriatic arthritis
The therapeutic focus extends to targeted immunomodulatory therapies for persistent inflammatory disease and organ-specific autoimmune manifestations.
Dermatology and inflammatory skin disease
Research involvement covers atopic dermatitis, hidradenitis suppurativa, vitiligo, psoriasis, alopecia areata, and subacute cutaneous lupus erythematosus, reflecting a strong interest in chronic immune-mediated skin disorders.
- Atopic dermatitis
- Hidradenitis suppurativa
- Vitiligo
- Psoriasis
- Alopecia areata
Therapeutic interest also includes cutaneous lupus subtypes and other refractory dermatologic conditions requiring advanced anti-inflammatory treatment options.
Respiratory and allergic disease
Clinical work spans asthma, chronic obstructive pulmonary disease, chronic rhinosinusitis, allergic rhinoconjunctivitis, and respiratory tract diseases, with interest in both airway inflammation and upper-airway disease.
- Asthma
- Chronic obstructive pulmonary disease
- Chronic rhinosinusitis
- Allergic rhinoconjunctivitis
- Severe eosinophilic asthma
The therapeutic landscape also includes nasal polyposis and severe inflammatory airway phenotypes that align with precision respiratory care.
Neurology and neuroimmunology
Investigational activity includes multiple sclerosis, primary progressive multiple sclerosis, relapsing-remitting multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, Parkinson’s disease, epilepsy, and Tourette’s disorder.
- Multiple sclerosis
- Chronic inflammatory demyelinating polyneuropathy
- Parkinson’s disease
- Refractory partial onset epilepsy
- Tourette’s disorder
This area reflects a therapeutic interest in immune-mediated neurologic disease and symptomatic control in chronic neurodegenerative and seizure-related conditions.
Cardiometabolic, renal, and hepatic disorders
Research participation also covers atrial fibrillation, heart failure, hypertension, atherosclerotic cardiovascular disease, chronic kidney disease, renal impairment, chronic hepatitis B, and severe hypertriglyceridemia.
- Atrial fibrillation
- Heart failure
- Chronic kidney disease
- Chronic hepatitis B
- Severe hypertriglyceridemia
Additional interest is evident in stroke prevention, cardiovascular risk reduction, and liver-related therapeutic strategies in chronic disease.
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