Mariana Villegas S.

The investigator is involved in clinical studies spanning atrial fibrillation, stroke prevention, heart failure, coronary artery disease, myocardial infarction, and pulmonary hypertension, with additional interest in vascular risk and coagulation-related conditions.

• Atrial fibrillation and thromboembolic prevention
• Heart failure and preserved or reduced ejection fraction
• Ischaemic stroke and transient ischaemic attack
• Pulmonary arterial hypertension and related vascular disease

Research activity also includes hyperlipidaemia, hypertension, and cardiovascular outcomes in complex comorbidity settings.

Clinical trial involvement covers a broad spectrum of solid tumours, including breast cancer, prostate cancer, lung cancer, colorectal cancer, pancreatic cancer, and melanoma, with further activity in urothelial cancer, cholangiocarcinoma, and other advanced malignancies.

• Breast, prostate, and ovarian cancers
• Non-small cell and small-cell lung cancer
• Colorectal, pancreatic, and gastric cancers
• Melanoma and other advanced solid tumours

There is also involvement in targeted therapy, immuno-oncology, and biomarker-guided cancer treatment.

Research interests include multiple sclerosis, Parkinson’s disease, epilepsy, Alzheimer’s disease, and myasthenia gravis, together with immune-mediated disorders such as rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis, and atopic dermatitis.

• Multiple sclerosis and other demyelinating disorders
• Neurodegenerative disease and cognitive decline
• Autoimmune and inflammatory rheumatic disease
• Atopic dermatitis and chronic immune-mediated skin disease

Additional therapeutic interest is seen in chronic obstructive pulmonary disease, asthma, and cystic fibrosis as part of broader inflammatory and respiratory care.

Clinical research also spans chronic kidney disease, glomerular disease, kidney transplant rejection, proteinuric nephropathies, and renal complications linked to cardiovascular and haematological disease, alongside diabetes, obesity, and dyslipidaemia.

• Chronic kidney disease and proteinuric glomerular disorders
• Kidney and lung transplant rejection
• Diabetes, obesity, and metabolic risk
• Hypertriglyceridaemia and familial lipid disorders

Activity in this domain also includes haemophilia, coagulation disorders, and pregnancy-related complications such as preeclampsia and ectopic pregnancy.