Mariana I. G.
- Country
- Bulgaria
- Department
- Rheumatology Clinic
Research Overview
- Evaluation of Long-Term Safety and Efficacy of Litifilimab in Adults with Active Systemic Lupus Erythematosus: A Phase 3 Multicenter, Randomized, Dose-Blind Study
- Effect of Upadacitinib on the Frequency of Acute Recurrent Anterior Uveitis in Patients With Axial Spondyloarthritis: A Real-World Study
- Phase II Randomized Study to Evaluate the Efficacy and Safety of AZD1163 in Participants with Moderately-to-Severely Active Rheumatoid Arthritis
Data & Insights
Has run more than one trial at 17 of 130 partner sites.
Specializations
Rheumatology and autoimmune disease
Clinical research activity is centered on rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren’s disease, and antiphospholipid syndrome, with additional interest in psoriatic arthritis, axial spondyloarthritis, and Behçet’s syndrome.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Systemic sclerosis
- Psoriatic arthritis
Therapeutic involvement also extends to cutaneous lupus erythematosus, lupus nephritis, and other immune-mediated inflammatory disorders affecting joints, skin, and internal organs.
Multiple sclerosis and neuroinflammation
The investigator is active in studies of relapsing multiple sclerosis, progressive multiple sclerosis, primary progressive multiple sclerosis, and secondary progressive multiple sclerosis, with attention to both inflammatory control and disability progression.
- Relapsing multiple sclerosis
- Progressive multiple sclerosis
- Primary progressive multiple sclerosis
- Secondary progressive multiple sclerosis
Research interests include disease-modifying therapies for neuroinflammation and long-term management of active and progressive demyelinating disease.
Gastroenterology and hepatology
Clinical trial involvement includes ulcerative colitis, Crohn’s disease, non-alcoholic steatohepatitis, chronic hepatitis B, and chronic hepatitis D, reflecting interest in inflammatory bowel disease and chronic liver disorders.
- Ulcerative colitis
- Crohn’s disease
- Non-alcoholic steatohepatitis
- Chronic hepatitis B
Therapeutic focus also covers immune-mediated liver inflammation and advanced treatment strategies for chronic viral and metabolic liver disease.
Hematology and lymphoid malignancies
Research activity spans chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, myelofibrosis, myeloproliferative neoplasms, and myelodysplastic syndromes, alongside selected studies in related marrow and blood disorders.
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Myelofibrosis
- Myeloproliferative neoplasms
The investigator’s portfolio also includes multiple myeloma and other B-cell malignancies, supporting ongoing evaluation of targeted and immune-based hematologic therapies.
Other immune-mediated and specialty disorders
Additional clinical interests include uveitis, immune thrombocytopenia, IgA nephropathy, immune-mediated focal segmental glomerulosclerosis, alopecia areata, and erythropoietic protoporphyria.
- Acute anterior uveitis
- Immune thrombocytopenia
- IgA nephropathy
- Erythropoietic protoporphyria
There is also involvement in osteoarthritis, epilepsy, lung cancer, and urothelial cancer, indicating a broad therapeutic reach across inflammatory, neurologic, and oncologic conditions.
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