Mariana B. O.

Her oncology research includes multiple advanced solid tumors, especially breast cancer, non-small cell lung cancer, colorectal cancer, gastric cancer, pancreatic cancer, hepatocellular carcinoma, and urothelial carcinoma. She is also involved in studies targeting melanoma, renal cell carcinoma, ovarian cancer, and head and neck squamous cell carcinoma.

• Breast cancer
• Non-small cell lung cancer
• Colorectal cancer
• Hepatobiliary cancers
• Melanoma

Her research landscape includes molecularly defined tumors such as KRAS-mutant, EGFR-mutated, HER2-positive, and PIK3CA-mutated cancers, highlighting a therapeutic focus on biomarker-driven treatment strategies.

Mariana Bastos Orteiro is active in trials addressing systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, and systemic sclerosis. Her portfolio also includes atopic dermatitis, hidradenitis suppurativa, plaque psoriasis, and Sjögren’s syndrome.

• Autoimmune rheumatic disease
• Dermatologic inflammation
• Systemic autoimmune disease
• Inflammatory bowel disease
• Vasculitic and connective tissue disorders

She is also involved in research on Crohn’s disease, ulcerative colitis, eosinophilic esophagitis, and giant cell arteritis, showing a broad therapeutic interest in immune dysregulation across organ systems.

Her clinical studies include chronic liver disease, metabolic dysfunction-associated steatohepatitis, non-alcoholic steatohepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and hepatocellular carcinoma. She is also involved in research on chronic kidney disease, IgA nephropathy, Fabry disease, and kidney transplant.

• Cholestatic liver disease
• Fibrotic liver disease
• Chronic kidney disease
• Glomerular disease
• Metabolic liver disease

Her research also spans obesity, type 2 diabetes, and cardiometabolic risk, linking hepatic and renal disease with broader metabolic complications.

Mariana Bastos Orteiro participates in trials focused on heart failure, atherosclerotic cardiovascular disease, myocardial infarction, stroke prevention, pulmonary arterial hypertension, and symptomatic hypertrophic cardiomyopathy. Her research also includes chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and progressive pulmonary fibrosis.

• Heart failure
• Ischemic cardiovascular disease
• Pulmonary hypertension
• Chronic obstructive pulmonary disease
• Pulmonary fibrosis

She is also involved in studies addressing venous thromboembolism and cardiovascular disease prevention, underscoring a therapeutic interest in high-burden cardiopulmonary disorders.