MARIA LUISA M. G.
- Country
- Spain
- Department
- Neurology
Research Overview
- Efficacy and Safety of Remibrutinib in Patients with Secondary Progressive Multiple Sclerosis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study
- A Phase 3 Non-inferiority Study Comparing Subcutaneous versus Intravenous Administration of Frexalimab in Adults with Multiple Sclerosis
- Phase 3 Randomized Double-Blind Study of Orelabrutinib for Primary Progressive Multiple Sclerosis in Patients With PPMS
Data & Insights
Has run more than one trial at 268 of 448 partner sites.
Specializations
Neurology and Neurodegenerative Disorders
Clinical research activity in Neurology includes studies in multiple sclerosis, relapsing-remitting multiple sclerosis, primary progressive multiple sclerosis, secondary progressive multiple sclerosis, Parkinson's disease, and migraine, with interest in conditions affecting central nervous system function and long-term neurological disability.
- Multiple sclerosis
- Parkinson's disease
- Migraine
- Progressive forms of multiple sclerosis
The therapeutic focus also extends to autoimmune encephalitis, Tourette's disorder, childhood epilepsy, and progressive supranuclear palsy, reflecting involvement in both inflammatory and degenerative neurological disease areas.
Autoimmune and Inflammatory Disease
Research involvement covers systemic lupus erythematosus, lupus nephritis, Sjögren's syndrome, rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis, with a clear therapeutic interest in immune-mediated disorders requiring targeted control of inflammation.
- Systemic lupus erythematosus
- Lupus nephritis
- Rheumatoid arthritis
- Psoriatic arthritis
- Sjögren's syndrome
Additional activity includes idiopathic inflammatory myopathies, dermatomyositis, vasculitis, and immune thrombocytopenia, supporting a broad interest in systemic autoimmune disease management.
Oncology and Hematologic Malignancies
The oncology portfolio includes studies in non-small cell lung cancer, breast cancer, colorectal cancer, ovarian cancer, melanoma, and gastroesophageal cancer, alongside strong participation in hematologic malignancies such as multiple myeloma, acute myeloid leukemia, lymphoma, and chronic lymphocytic leukemia.
- Non-small cell lung cancer
- Breast cancer
- Multiple myeloma
- Acute myeloid leukemia
- Lymphoma
Clinical interest also spans solid tumors, urothelial carcinoma, pancreatic cancer, and hepatocellular carcinoma, indicating broad engagement across both solid and blood cancers.
Cardiovascular and Metabolic Medicine
Investigational work includes atherosclerotic cardiovascular disease, heart failure, myocardial infarction, stroke prevention, and resistant hypertension, with attention to cardiovascular risk reduction and disease progression.
- Atherosclerotic cardiovascular disease
- Heart failure
- Acute ischemic stroke
- Resistant hypertension
- Dyslipidemia
Therapeutic interests further include type 2 diabetes, obesity, chronic kidney disease, and metabolic dysfunction-associated steatohepatitis, reflecting a clinical profile that connects cardiometabolic disease with organ protection.
Respiratory, Infectious, and Gastrointestinal Disorders
Research activity also covers chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, bronchiectasis, and acute respiratory distress syndrome, showing interest in chronic and severe pulmonary disease.
- Chronic obstructive pulmonary disease
- Asthma
- Idiopathic pulmonary fibrosis
- Acute respiratory distress syndrome
Additional involvement includes COVID-19, severe bacterial infections, Clostridioides difficile infection, Crohn's disease, and ulcerative colitis, highlighting therapeutic interest in infection-related illness and inflammatory gastrointestinal disease.
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