Maria Lucia C.
- Country
- Italy
- Department
- UOC medicina nucleare
Research Overview
Data & Insights
Has run more than one trial at 0 of 21 partner sites.
Specializations
Oncologic Imaging and Theranostics
The investigator applies Positron Emission Tomography combined with computed tomography to delineate tumor biology and to guide radiopharmaceutical therapy across a spectrum of solid malignancies.
- Radiolabeled peptide therapy for neuroendocrine tumors
- Prostate‑specific membrane antigen (PSMA) imaging and treatment
- HER2‑directed radiopharmaceuticals for breast cancer
Research is conducted at Fondazione Policlinico Universitario Agostino Gemelli IRCCS, integrating diagnostic precision with targeted radionuclide delivery.
Cardiovascular Molecular Imaging
Advanced myocardial perfusion imaging techniques are employed to evaluate coronary artery disease, while novel tracers visualize vascular inflammation and plaque activity.
- Quantitative assessment of myocardial blood flow
- Inflammatory plaque detection using radiolabeled agents
- Imaging of IL‑6 mediated vascular inflammation
The work supports risk stratification and therapeutic monitoring for patients with acute coronary syndromes and chronic heart failure.
Liver Disease Imaging and Metabolic Assessment
Specialized hepatic fat quantification and fibrosis staging are performed with PET tracers that reflect metabolic activity and extracellular matrix remodeling.
- Non‑alcoholic steatohepatitis (NASH) activity measurement
- Fibrosis progression monitoring via radiotracer uptake
- Metabolic tracer studies in obesity‑related liver disease
These approaches aim to identify early disease and evaluate response to emerging anti‑fibrotic therapies.
Infectious Disease Nuclear Diagnostics
Targeted imaging of pulmonary infections utilizes radiolabeled antibiotic tracers to detect active mycobacterial burden and assess treatment efficacy.
- Mycobacterium avium complex (MAC) infection visualization
- Quantitative pulmonary infection burden assessment
- Monitoring of antimicrobial therapy response
The methodology provides a non‑invasive tool for managing complex respiratory infections in immunocompromised patients.
Autoimmune and Inflammatory Disease Imaging
Innovative immune cell tracking strategies enable visualization of systemic inflammation in conditions such as lupus, myasthenia gravis, and systemic sclerosis.
- Biomarker imaging for disease activity in systemic lupus erythematosus
- Assessment of neuromuscular junction pathology in myasthenia gravis
- Therapeutic response monitoring in systemic sclerosis
These studies support personalized treatment decisions for patients with chronic autoimmune disorders.
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