Maria José D. M. L.
- Country
- Spain
- Department
- Oncology, Clínical Trials Phase I START Madrid-CIOCC Centro Integral Oncologico Clara Campal
Research Overview
- Phase 1 Evaluation of SGN-ALPV in Patients with Advanced Solid Tumors Including GEJ Carcinoma, NSCLC, Gastric, Cervical, Ovarian, and Endometrial Cancers
- Pharmacokinetic and Safety Evaluation of Oral Decitabine and Cedazuridine in Patients with Solid Tumors, Myelodysplastic Syndrome, or Acute Myeloid Leukemia with Hepatic Impairment
- Pharmacokinetic and Safety Evaluation of Oral Decitabine and Cedazuridine in Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Solid Tumors with Renal Impairment
Data & Insights
Has run more than one trial at 73 of 159 partner sites.
Specializations
Hormone Receptor Positive Breast Cancer
Investigation of Estrogen Receptor Positive HER2 Negative disease biology and novel endocrine combinations.
- ER+/HER2- Advanced Breast Cancer
- HR+ Breast Cancer
- Neoadjuvant Endocrine Therapy
- BRCA‑mutated Breast Tumors
- HER2‑low Breast Cancer
Emphasis on molecular sub‑typing and resistance mechanisms in metastatic settings.
Non‑Small Cell Lung Cancer
Targeted exploration of driver mutations and immunologic pathways in advanced disease.
- KRAS G12C Mutant NSCLC
- ALK‑rearranged NSCLC
- EGFR Exon 20 Insertion NSCLC
- PD‑L1 Negative NSCLC
- Squamous NSCLC
Focus includes both first‑line and refractory disease contexts.
Gastrointestinal and Hepatobiliary Malignancies
Broad activity across upper and lower gastrointestinal tract cancers and primary liver tumors.
- Metastatic Colorectal Cancer
- Advanced Gastric Adenocarcinoma
- Pancreatic Ductal Adenocarcinoma
- Cholangiocarcinoma
- Hepatocellular Carcinoma
Investigations address refractory disease and biomarker‑driven subpopulations.
Gynecologic Oncology
Comprehensive study of female reproductive tract cancers with emphasis on molecular heterogeneity.
- High‑Grade Serous Ovarian Cancer
- Platinum‑Resistant Ovarian Cancer
- Endometrial Carcinoma
- Cervical Cancer
- Fallopian Tube Carcinoma
Research includes both metastatic and localized disease settings.
Hematologic and Rare Solid Tumors
Targeted approaches for blood‑borne malignancies and uncommon solid tumor entities.
- Acute Myeloid Leukemia
- Myelodysplastic Syndromes
- Diffuse Large B‑Cell Lymphoma
- Melanoma
- Mesothelioma
Efforts focus on genetic drivers and novel therapeutic modalities.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.