Maria Irene M. J.
- Country
- Spain
- Department
- Endocrinology and nutrition
Research Overview
- Evaluation of Long-term Safety and Tolerability of Apraglutide in Patients with Short Bowel Syndrome-Intestinal Failure
- A Phase 3, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Multicenter Trial to Confirm the Efficacy and Safety of Glepaglutide 10 mg Twice-Weekly, Followed by a Long-Term, Open-Label Safety Evaluation in Patients with Short Bowel Syndrome–Intestinal Failure (SBS-IF)
Data & Insights
Has run more than one trial at 17 of 52 partner sites.
Specializations
Oncology and solid tumor care
Clinical activity centers on advanced and metastatic malignancies, with strong involvement in breast cancer, non-small cell lung cancer, urothelial carcinoma, renal cell carcinoma, and gastrointestinal cancers. The trial portfolio also includes ovarian cancer, endometrial cancer, head and neck squamous cell carcinoma, hepatocellular carcinoma, and pancreatic adenocarcinoma.
- Precision oncology in biomarker-defined tumors
- HER2-related and hormone receptor-positive breast cancer
- Lung cancer and thoracic malignancies
- Genitourinary and gastrointestinal oncology
Work in this area reflects a focus on treatment-resistant and recurrent disease, including molecularly selected populations and advanced solid tumors requiring new therapeutic options.
Hematologic malignancies and cellular therapy
Research interests extend across lymphomas, leukemias, and plasma cell disorders, including diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, multiple myeloma, and myelodysplastic syndromes.
- B-cell non-Hodgkin lymphoma
- Acute myeloid leukemia
- Multiple myeloma
- Myelofibrosis and related myeloproliferative disorders
The portfolio also includes graft-versus-host disease and post-transplant hematology, indicating involvement in immune-mediated complications linked to hematologic treatment.
Autoimmune and inflammatory diseases
Therapeutic interests include immune-mediated disorders such as psoriatic arthritis, ulcerative colitis, Crohn’s disease, systemic lupus erythematosus, lupus nephritis, atopic dermatitis, and bullous pemphigoid. Additional activity is seen in rheumatoid arthritis, hidradenitis suppurativa, and systemic sclerosis.
- Inflammatory bowel disease
- Connective tissue diseases
- Chronic inflammatory skin disease
- Autoimmune kidney involvement
This area also covers broader immune dysregulation and refractory inflammatory conditions, aligning with therapeutic development in difficult-to-control immune disorders.
Respiratory, allergic, and sleep-related disorders
Clinical research includes asthma, severe eosinophilic asthma, allergic rhinoconjunctivitis, chronic rhinosinusitis with nasal polyposis, interstitial lung disease, and pulmonary arterial hypertension. There is also involvement in obstructive sleep apnea in adults living with overweight or obesity.
- Severe asthma
- Allergic airway disease
- Interstitial lung disease
- Sleep-disordered breathing
The therapeutic scope spans chronic respiratory control, airway inflammation, and cardiopulmonary complications associated with advanced pulmonary disease.
Renal, cardiometabolic, and metabolic liver disease
Research activity also covers chronic kidney disease, proteinuric glomerular disease, IgA nephropathy, focal segmental glomerulosclerosis, complement-mediated kidney disease, and kidney transplant-related complications. Additional interests include heart failure, atherosclerotic cardiovascular disease, hyperlipidemia, and alcohol-related liver disease.
- Glomerular and transplant-related nephrology
- Heart failure and vascular risk
- Metabolic liver disease
- Obesity-associated complications
Her therapeutic landscape includes chronic organ disease management alongside emerging approaches for complex renal, hepatic, and cardiometabolic conditions.
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