Maria Helena L.
- Country
- Portugal
- Department
- Pediatrics
Research Overview
- A Phase 3b Extension Study to Evaluate the Long-Term Safety of Vedolizumab Subcutaneous in Pediatric Subjects With Ulcerative Colitis or Crohn’s Disease
- Phase 3 Evaluation of Vedolizumab Subcutaneous Pharmacokinetics, Safety, and Immunogenicity in Pediatric Patients with Moderate to Severe Ulcerative Colitis or Crohn's Disease
Data & Insights
Has run more than one trial at 20 of 30 partner sites.
Specializations
Pediatric Gastroenterology and Inflammatory Bowel Disease
Clinical research activity includes treatment-focused studies in ulcerative colitis and Crohn’s disease, with attention to disease control in younger patients and the management of chronic intestinal inflammation.
- Ulcerative colitis
- Crohn’s disease
- Pediatric inflammatory bowel disease
Interest extends to therapies supporting long-term disease management in pediatric medicine within the Department of Pediatrics.
Pulmonology and Chronic Airway Disease
Research involvement covers a broad respiratory landscape, including asthma, chronic obstructive pulmonary disease, bronchiectasis, and other persistent lung disorders requiring advanced therapeutic approaches.
- Asthma
- Chronic obstructive pulmonary disease
- Bronchiectasis
The respiratory portfolio also includes pulmonary arterial hypertension and interstitial lung disease, reflecting interest in complex cardiopulmonary treatment domains.
Oncology and Hematologic Malignancies
Clinical trial activity spans multiple cancer types, with emphasis on lung cancer, breast cancer, colorectal cancer, bladder cancer, and lymphoid and myeloid malignancies.
- Non-small cell lung cancer
- Breast cancer
- Acute myeloid leukemia
Additional therapeutic interest includes head and neck cancer, ovarian cancer, multiple myeloma, and lymphoma, supporting innovation across solid and blood cancers.
Neurology and Neurodegenerative Disease
Research involvement includes disorders such as epilepsy, multiple sclerosis, migraine, Parkinson’s disease, and broader neurodegenerative diseases.
- Epilepsy
- Multiple sclerosis
- Migraine
The portfolio also includes rare neurologic conditions such as spinocerebellar ataxia and developmental and epileptic encephalopathies, indicating engagement with specialized neurologic therapies.
Autoimmune, Renal, and Cardiovascular Disorders
Additional trial activity spans systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, Sjögren’s disease, lupus nephritis, focal segmental glomerulosclerosis, and chronic kidney disease.
- Systemic lupus erythematosus
- Focal segmental glomerulosclerosis
- Heart failure
Cardiovascular interests include atrial fibrillation, stroke prevention, heart failure, and atherosclerotic cardiovascular disease, alongside selected metabolic and liver-related conditions such as obesity and non-alcoholic steatohepatitis.
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