Maria G.
- Country
- Italy
- Department
- Allergy Unit
Research Overview
- Phase II Double-Blind, Placebo-Controlled Study of PHA-022121 for Prophylaxis of Hereditary Angioedema Attacks in C1-Inhibitor Deficiency Patients
- Evaluation of Long-term Safety and Efficacy of Deucrictibant Extended-Release Tablets for Prophylactic Management of Hereditary Angioedema in Adolescents and Adults
Data & Insights
Has run more than one trial at 6 of 32 partner sites.
Specializations
Hereditary Angioedema
Maria Guarino is involved in clinical research on hereditary angioedema, with a therapeutic focus on preventing recurrent swelling attacks and improving long-term disease control in patients managed through the Allergy Unit.
- Long-term prophylaxis for angioedema attacks
- Hereditary angioedema due to C1-inhibitor deficiency
- Symptom prevention in adults and adolescents
Her research activity in this area includes evaluation of oral preventive therapies aimed at reducing attack burden and supporting sustained management of chronic angioedema.
Acute Myeloid Leukemia
Her clinical research also extends to acute myeloid leukemia, with interest in treatment strategies for newly diagnosed patients who are not candidates for intensive chemotherapy and in disease subtypes defined by molecular features.
- NPM1-mutated AML
- Favorable-intermediate-risk AML
- Therapy for newly diagnosed adult patients
This area reflects involvement in hematologic oncology studies focused on improving survival outcomes and remission rates through targeted and combination treatment approaches.
Targeted Hematologic Therapy
Maria Guarino is engaged in research on targeted treatment approaches in hematologic malignancies, including therapies designed to enhance response depth and support measurable disease control in AML.
- Revumenib combinations
- Gemtuzumab ozogamicin with chemotherapy
- Minimal residual disease assessment
Her work in this domain centers on treatment strategies that integrate novel agents with standard regimens to refine remission outcomes in leukemia care.
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