Maria Angeles M. D.
- Country
- Spain
- Department
- Servicio de Dermatologia
Research Overview
- OptIMMize-2: A Phase 3 Multicenter, Single-arm, Open-label Extension Study to Assess the Safety, Tolerability, and Efficacy of Risankizumab in Subjects With Moderate to Severe Plaque Psoriasis Who Have Completed Participation in Study M19-977 (OptIMMize-1).
- A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Combination with Topical Corticosteroids in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
- Evaluation of Lebrikizumab Efficacy and Safety in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: A Phase 3 Randomized Study
Data & Insights
Has run more than one trial at 28 of 167 partner sites.
Specializations
Dermatology and inflammatory skin disease
Clinical research activity in atopic dermatitis, plaque psoriasis, alopecia areata, hidradenitis suppurativa, vitiligo, and cutaneous lupus erythematosus, with additional involvement in ulcerative pyoderma gangrenosum and other chronic inflammatory dermatoses.
- Atopic dermatitis
- Plaque psoriasis
- Alopecia areata
- Hidradenitis suppurativa
- Cutaneous lupus erythematosus
Work in this area also extends to systemic lupus erythematosus and primary Sjögren’s disease, reflecting a strong therapeutic focus on immune-mediated skin and connective tissue disorders.
Respiratory and allergic disease
Research interests include asthma, severe eosinophilic asthma, allergic rhinoconjunctivitis, eosinophilic esophagitis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and pulmonary sarcoidosis.
- Asthma
- Allergic rhinoconjunctivitis
- Eosinophilic esophagitis
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
Additional involvement covers progressive pulmonary fibrosis, severe community-acquired bacterial pneumonia, and tuberculosis, highlighting therapeutic interest in airway inflammation, fibrotic lung disease, and respiratory infection.
Hematology and oncology
Clinical trial activity includes multiple myeloma, chronic lymphocytic leukemia, small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, and marginal zone lymphoma.
- Multiple myeloma
- Chronic lymphocytic leukemia
- Follicular lymphoma
- Mantle cell lymphoma
- Diffuse large B-cell lymphoma
Participation also spans acute myeloid leukemia, breast cancer, non-small cell lung cancer, and head and neck squamous cell carcinoma, with a clear emphasis on targeted and immunologic cancer therapies.
Autoimmune, renal, and gastrointestinal disorders
Research involvement extends to psoriatic arthritis, idiopathic inflammatory myopathies, systemic lupus erythematosus, primary immune thrombocytopenia, IgA nephropathy, Crohn's disease, and ulcerative colitis.
- Psoriatic arthritis
- Idiopathic inflammatory myopathies
- Primary immune thrombocytopenia
- IgA nephropathy
- Inflammatory bowel disease
Additional therapeutic interest includes Sjögren’s syndrome, chronic hepatitis B, and gout with hyperuricemia, covering systemic immune dysregulation and related organ-specific complications.
Infectious, metabolic, and cardiovascular conditions
Clinical research also includes HIV infection, COVID-19, chronic hepatitis B, metabolic liver disease, type 2 diabetes, atherosclerotic cardiovascular disease, acute heart failure, and venous thromboembolism.
- HIV infection
- COVID-19
- Metabolic liver disease
- Type 2 diabetes
- Atherosclerotic cardiovascular disease
The portfolio also touches on acute anticoagulation reversal and chronic renal disease, reflecting engagement with medically complex conditions across infectious, metabolic, and vascular care.
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