Marchela K.
- Country
- Bulgaria
- Department
- Oncology
Research Overview
- Phase 1 Study of PAS-004, a MEK (1/2) Inhibitor, in MAPK Pathway-driven Advanced Solid Tumors with RAS, NF1, or RAF Mutations or Post-BRAF/MEK Inhibition Failure
- Pharmacokinetic Comparison of FYB206 and Pembrolizumab in Adjuvant Treatment of Stage IIB, IIC, or III Melanoma Post-Resection
- Evaluation of Saruparib Safety and Pharmacodynamics in Adults with Advanced Solid Malignancies
Data & Insights
Has run more than one trial at 86 of 315 partner sites.
Specializations
Thoracic Oncology and Solid Tumors
Clinical research in medical oncology with a strong focus on non-small cell lung cancer, including HER2-mutated and EGFR-mutated disease, as well as broader advanced solid malignancies and head and neck squamous cell carcinoma.
- Non-small cell lung cancer
- Head and neck squamous cell carcinoma
- Advanced non-clear cell renal cell carcinoma
- Melanoma
- Cancer cachexia
Research activity also extends to combination immunotherapy and treatment strategies for metastatic cancer and tumor-related weight loss.
Cardiovascular and Thrombotic Disease
Investigator involvement includes studies in atherosclerotic cardiovascular disease, heart failure, hypertension, hypercholesterolemia, atrial fibrillation, and prevention of major adverse cardiovascular events.
- Heart failure
- Atrial fibrillation
- Acute myocardial infarction
- Venous thromboembolism
- Hypertriglyceridemia
Additional interest is seen in lipid-lowering therapy, thromboprophylaxis, and cardiovascular risk reduction in patients with established or high-risk disease.
Immune-Mediated and Inflammatory Disorders
Clinical work spans psoriasis, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and related autoimmune conditions.
- Plaque psoriasis
- Ulcerative colitis
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Sjögren's syndrome
Research also includes atopic dermatitis, alopecia areata, and other immune-mediated inflammatory diseases requiring targeted therapeutic approaches.
Hepatology, Respiratory, and Metabolic Conditions
Interest extends to chronic hepatitis B, chronic hepatitis D, hepatic encephalopathy, chronic obstructive pulmonary disease, non-cystic fibrosis bronchiectasis, and metabolic disorders linked to cardiovascular risk.
- Chronic hepatitis B infection
- Hepatic encephalopathy
- Chronic obstructive pulmonary disease
- Non-cystic fibrosis bronchiectasis
- Hypertriglyceridemia
Work in this area also covers obesity-associated heart failure and lipoprotein(a)-related cardiovascular risk.
Ophthalmology and Hematologic Supportive Care
Additional clinical research includes retinal vein occlusion, geographic atrophy, open-angle glaucoma, and ocular hypertension, alongside supportive care in chemotherapy-induced thrombocytopenia and inherited bleeding disorders.
- Geographic atrophy
- Open-angle glaucoma
- Ocular hypertension
- Chemotherapy-induced thrombocytopenia
- Hemophilia
These areas reflect involvement in therapies for vision-threatening disease and treatment-related blood count complications in oncology care.
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