Marcello D. N.
- Country
- Italy
- Department
- Vascular Surgery
Research Overview
- Efficacy and Safety of Low-Dose Colchicine in Preventing Post-Thrombotic Syndrome in Patients with Proximal Lower-Extremity Deep Vein Thrombosis: A Randomized Controlled Trial
- Efficacy and Safety of Low-Dose Colchicine in Reducing Cardiovascular Events in Patients with Peripheral Arterial Disease: A Randomized Controlled Trial
- Evaluation of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Patients with Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, and Systemic Inflammation
Data & Insights
Has run more than one trial at 4 of 253 partner sites.
Specializations
Cardiovascular medicine and vascular risk
Clinical activity in cardiovascular disease focuses on prevention of recurrent events, management of high-risk vascular profiles, and treatment strategies for acute coronary syndrome, myocardial infarction, and unstable angina. The portfolio also includes peripheral arterial disease, venous thromboembolism, and broader atherosclerotic cardiovascular disease.
- Coronary and vascular event prevention
- Thromboembolic disease
- Peripheral and supra-aortic arterial disease
Additional involvement extends to cardiometabolic risk reduction in people with type 2 diabetes, obesity, and elevated cardiovascular risk.
Kidney disease and cardio-renal therapy
Research interests include chronic kidney disease, end-stage kidney disease, IgA nephropathy, and kidney involvement linked to type 1 diabetes and type 2 diabetes mellitus. The therapeutic landscape also covers peritoneal dialysis and peritoneal ultrafiltration.
- Proteinuria reduction
- Diabetic kidney disease
- Peritoneal renal replacement therapy
Work in this area reflects interest in therapies for cardio-renal syndrome and progressive renal injury.
Neurology and neurodegenerative disorders
The investigator is active in studies of Parkinson disease, multiple sclerosis, Alzheimer’s disease, and epilepsy. This includes attention to relapsing multiple sclerosis, progressive multiple sclerosis, primary progressive multiple sclerosis, and seizure disorders such as focal onset seizures and generalized tonic-clonic seizures.
- Parkinsonian syndromes
- Demyelinating disease
- Seizure control
Therapeutic interests also extend to mild cognitive impairment and neurogenic orthostatic hypotension.
Inflammatory skin disease and rheumatology
Clinical research includes atopic dermatitis, hidradenitis suppurativa, prurigo nodularis, and psoriasis, alongside systemic inflammatory conditions such as rheumatoid arthritis and juvenile idiopathic arthritis. These activities reflect a strong therapeutic focus on chronic immune-mediated disease.
- Atopic and eczematous disorders
- Neutrophilic and nodular skin disease
- Inflammatory arthritis
The research profile also includes systemic inflammation and immune-mediated disorders with cutaneous and musculoskeletal involvement.
Metabolic, oncologic, and other therapeutic areas
Additional interests span type 2 diabetes, weight management, and obesity, together with selected oncology topics including prostate cancer, ovarian cancer, rectal cancer, breast cancer, and melanoma. The portfolio also touches on treatment-resistant depression and neuromyelitis optica spectrum disorder.
- Glycemic and weight-related disorders
- Solid tumor oncology
- Selected neuroimmune and psychiatric conditions
These areas show involvement in therapies aimed at chronic metabolic disease, malignancy, and complex multisystem conditions.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.